balsalazide


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balsalazide

 [bal-sal´ah-zīd]
a prodrug of the antiinflammatory mesalamine, to which it is converted in the colon; administered orally as the disodium salt in the treatment of ulcerative colitis.

balsalazide

Colazal® Internal medicine An agent that delivers concentrated 5-aminosalicylic acid to the colonic mucosa in Pts with ulcerative colitis. See Ulcerative colitis.

balsalazide

A drug used in the treatment of ULCERATIVE COLITIS. A brand name is Colazide.
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References in periodicals archive ?
* Aminosalicylates: Sulfasalazine (Azulfidine), olsalazine (Dipentum), mesalamine (Apriso, Asacol), balsalazide (Colazol)
Sandborn, "Balsalazide and azathiprine or 6-mercaptopurine: evidence for a potentially serious drug interaction," Gastroenterology, vol.
Mackowiak, "A two-stage decision analysis to assess the cost of 5-aminosalicylic acid failure and the economics of balsalazide versus mesalamine in the treatment of ulcerative colitis," Managed Care Interface, vol.
* Aminosalicylates, such as mesalamine (Lialda), mesalamine extended-release (Apriso), olsalazine (Dipentum), and balsalazide (Colazal)
Common aminosalicylates used in IBD include sulfasalazine, balsalazide, mesalamine, and olsalazine.
The most frequently prescribed aminosalicylates used to treat IBD are mesalazine, sulfasalazine, olsalazine, and balsalazide. Although the therapy is widely used, especially to treat UC patients, it can present some adverse effects.
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide, sulfasalazine, 6-mercaptopurine, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab)."
* 5-Aminosalicylic acid derivative agents (e.g., mesalamine rectal, mesalamine, sulfasalazine, balsalazide)
He had been maintained on balsalazide (5-ASA), metronidazole, adalimumab, and omeprazole.
Antienflamatuar olarak kullanilan 5-ASA preparatlari barsagin ust kisminda emildiginden dolayi, emilinin distal ince barsak ve kolonda olabilmesi icin absorbe olmayan tasiyicilara baglanarak gelistirilmistir (Olsalazine, mesalamin, balsalazide).
This group includes mesalamine, or 5-aminosalicylic acid (5-ASA), sulphasalazine, olsalazine, and balsalazide. Corticosteroids are also frequently used for the treatment of IBD.
The prodrugs sulfasalazine, olsalazine and balsalazide rely on colonic bacterial enzymes to metabolize the inactive precursor to the active drug mesalazine.