* Aminosalicylates: Sulfasalazine (Azulfidine), olsalazine (Dipentum), mesalamine (Apriso, Asacol), balsalazide
and azathiprine or 6-mercaptopurine: evidence for a potentially serious drug interaction," Gastroenterology, vol.
Mackowiak, "A two-stage decision analysis to assess the cost of 5-aminosalicylic acid failure and the economics of balsalazide
versus mesalamine in the treatment of ulcerative colitis," Managed Care Interface, vol.
* Aminosalicylates, such as mesalamine (Lialda), mesalamine extended-release (Apriso), olsalazine (Dipentum), and balsalazide
Common aminosalicylates used in IBD include sulfasalazine, balsalazide
, mesalamine, and olsalazine.
The most frequently prescribed aminosalicylates used to treat IBD are mesalazine, sulfasalazine, olsalazine, and balsalazide
. Although the therapy is widely used, especially to treat UC patients, it can present some adverse effects.
Children were defined as having IBD if they had either three or more health care visits for Crohn's disease or ulcerative colitis during the study's time frame, or "at least one health care contact for Crohn's disease or ulcerative colitis and at least one pharmacy claim for any of the following medications: mesalamine, olsalazine, balsalazide
, sulfasalazine, 6-mercaptopurine, azathioprine, methotrexate, enteral budesonide, or biologies (infliximab, adalimumab, certolizumab, or natalizumab)."
He had been maintained on balsalazide
(5-ASA), metronidazole, adalimumab, and omeprazole.
Antienflamatuar olarak kullanilan 5-ASA preparatlari barsagin ust kisminda emildiginden dolayi, emilinin distal ince barsak ve kolonda olabilmesi icin absorbe olmayan tasiyicilara baglanarak gelistirilmistir (Olsalazine, mesalamin, balsalazide
This group includes mesalamine, or 5-aminosalicylic acid (5-ASA), sulphasalazine, olsalazine, and balsalazide
. Corticosteroids are also frequently used for the treatment of IBD.
The prodrugs sulfasalazine, olsalazine and balsalazide
rely on colonic bacterial enzymes to metabolize the inactive precursor to the active drug mesalazine.