The table reviews the findings of prior bacteriologic
examinations of chronic sinusitis, as well as those of the present study.
cure was significantly more likely with cephalosporin treatment (92.
WHO treatment outcomes include bacteriologic
cure: patients with a positive smear or culture before treatment and negative bacteriologic
results at the end of therapy; treatment completion: patients who complete treatment without bacteriologic
proof of cure or failure; treatment failure: patients who fail to achieve bacteriologic
conversion within 5 months after the start of treatment, who become smear-or culture-positive again during treatment after a previous conversion, or who are identified with multidrug-resistant TB (i.
daily isoniazid, pyrazinamide, rifampin, and ethambutol or streptomycin) for a minimum of 2 months and until bacteriologic
response is achieved (i.
We retrieved data from 2 databases: one at the National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, which contains the bacteriologic
information of all M.
The topical group had a clinical response rate of 100% and a bacteriologic
cure rate of 95%, and the topical/oral group had rates of 95 and 85%, respectively.
The authors included 35 trials involving 7,125 patients in their study, and found that the overall odds ratios for bacteriologic
and clinical cure rates significantly favored cephalosporins.
Nevertheless, the prevailing treatment for AOE is still a topical antibiotic that (1) can be delivered at extremely high concentrations directly to the site of infection, (2) is bactericidal, and (3) can facilitate a rapid clinical and bacteriologic
cure, thereby preventing a secondary complication (e.
4% of the ciprofloxacin group experienced bacteriologic
success rate was 92% with moxifloxacin and 81% with the other drugs.