baclofen withdrawal syndrome

baclofen withdrawal syndrome

A symptom complex that follows abrupt withdrawal from baclofen (Kemstro, Lioresal), a GABA (gamma-aminobutyric acid) antagonist used to manage spinal spasticity.
 
Clinical findings
Hallucinations (auditory, visual and tactile), confusion, agitation, delirium, disorientation, fluctuation of consciousness, insomnia, memory impairments, anxiety, depersonalisation, hypertonia, psychosis, mania, mood disturbances, restlessness, behavioural disturbances, tachycardia, seizures, tremors, autonomic dysfunction, hyperpyrexia, extreme muscle rigidity resembling neuroleptic malignant syndrome and rebound spasticity.
References in periodicals archive ?
Bethany then developed Baclofen withdrawal syndrome, sending her muscles into violent spasms and causing the fatal rhabdomyolysis.
A baclofen withdrawal syndrome can occur with rapid cessation of usage.