beta-lactamase

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β-lac·ta·mase

(lak'tă-mās),
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity. The ability of an organism to produce a β-lactamase may be chromosomal and constitutive or a plasmid-associated acquired property.

beta-lactamase

(bā′tə-lăk′tə-mās′, -māz′, bē′-)
n.
Any of various enzymes that hydrolyze and inactivate beta-lactam antibiotics such as penicillin, found in many antibiotic-resistant bacteria.

be·ta-lac·ta·mase

(bā'tă lak'tā-mās)
An enzyme produced by many species of bacteria that disrupts the four-membered β-lactam ring of penicillin and cephalosporin groups of antibiotics, destroying their antimicrobial activity.
Synonym(s): penicillinase.
References in periodicals archive ?
Genotypes of TEM-type and CTX-M-type extended-spectrum b-Lactamases produced by E.
Isolates were screened for AmpC b-lactamase production by disc diffusion method as described by Clinical Laboratory Standards Institute (CLSI).8
and Noor, R., Study of extended spectrum b-lactamase producing bacteria from urinary tract infection in Dhaka city, Bangladesh.
Plasmid mediated AmpC b-lactamase producing Klebsiella (K.) pneumoniae and Escherichia (E.) coli have been responsible for nosocomial outbreaks of infections and colonisation.7 AmpC b-lactamases are associated with erroneous antimicrobial susceptibility in routine testing.8 AmpC b-lactamases are not inhibited by b-lactamase inhibitors such as clavulanic acid.3 Strains with AmpC genes are often resistant to multiple antibiotic.
KEY WORDS: b-Lactamase (bla) gene, Large-scale detection, Molecular diagnosis, Minimizing antibiotic resistance.
CTX-M extended-spectrum b-lactamase, Washington State.
There was no compatibility between b-lactamase production and antibiotic resistance.
Two disadvantages are its ineffectiveness against B-lactamase producing pathogens, and its inability to be used in clients with penicillin allergies.
The prevalence of extended spectrum b-lactamase phenomenon was 220(100%) in Klebsiella pneumoniae, 195(75%) in Escherichia coli.
This increase in the zone size is due to inactivation of B-lactamase by clavulanic acid.
(7.) Naas T, Cuzon G, Villegas MV, Lartigue MF, Quinn JP, Nordmann P Genetic structures at the origin of acquisition of the b-lactamase [bla.sub.KPC] gene.