azurophilic granule


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azurophilic granule

A large, coarse, blue-purple membrane-bound organelle in progranulocytes, myelocytes and neutrophils, which acts as a reservoir for digestive and hydrolytic enzymes before delivery to a phagosome.

azurophilic granule

A small red or reddish-purple granule that easily takes a stain with azure dyes. Found in lymphocytes and monocytes, it is inconstant in number, being present in about 30% of the cells.
See also: granule
References in periodicals archive ?
In eliptical thrombocytes, the cytoplasma presented itself hyaline of a vacuoloid aspect especially in the poles, sometimes showing in one of the poles one of two azurophilic granules clearly visible in most of the thrombocytes.
(7) Fine or coarse azurophilic granules are often seen in the slightly pale or basophilic cytoplasm.
MPO, which is abundant in azurophilic granules of neutrophils and in the lysosomes of monocytes, plays a key role in amplifying the toxicity of hydrogen peroxide generated by the respiratory burst (1), (2).
The t(8; 21) subtype is characterized by large blasts with abundant basophilic cytoplasm, with perinuclear clearing or hofs, and numerous azurophilic granules. Very large cytoplasmic granules in the blasts are reminiscent of pseudo-Chediak-Higashi granules (Figure A).
The blasts in the peripheral blood varied in appearance from small cells showing lymphoid features with a high nucleus-cytoplasmic ratio, sparse cytoplasm, dense nuclear chromatin, and inconspicuous nucleoli to larger forms with a lower nucleus-cytoplasmic ratio, a moderate amount of basophilic cytoplasm, few fine perinuclear azurophilic granules, occasional cytoplasmic blebs or buds, dispersed nuclear chromatin, and distinct nucleoli.