azurophil


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azurophil

 [azh-u´ro-fil]
a tissue constituent staining with azure or a similar blue aniline dye.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

az·u·ro·phil

, azurophile (azh-ū'rō-fil, -fīl),
Staining readily with an azure dye, denoting especially the hyperchromatin and reddish purple granules of some blood cells.
[azure + G. philos, fond]
Farlex Partner Medical Dictionary © Farlex 2012

azurophil

adjective Referring to any substance or cell that stains with an azurophilic (blue aniline) dye—e.g., azurophilic cell, azurophilic granule.
 
noun Any substance or cell that stains with an azurophilic (blue aniline) dye—e.g., azurophilic cell, azurophilic granule.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

az·u·ro·phil

, azurophile (azh'ŭr-ō-fil, -fīl)
Staining readily with an azure dye, denoting especially the hyperchromatin and reddish-purple granules (i.e., azurophilic granules) of certain blood cells.
[azure + G. philos, fond]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Cathepsin G is one of the three serine proteases (along with proteinase-3 and elastase) that are contained in primary (azurophil) granules of neutrophils and involved in clearance of internalized pathogens, proteolytic modification of chemokines and cytokines, and shedding of cell surface receptors [55].
Hieblot et al., "Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules," Blood, vol.
Importantly, granule contents are also released according to a hierarchy, with secretory granules being the most readily exocytosed and azurophil granules only undergoing partial exocytosis [38].
Kew, "Upregulation of vitamin D binding protein (Gc-globulin) binding sites during neutrophil activation from a latent reservoir in azurophil granules," Molecular Immunology, vol.
Furthermore, [alpha]-defensin has not been detected in mouse neutrophils, (32) while human [alpha]-defensin is a major component of azurophil granules of human neutrophils.
Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against histoplasma capsulatum.
Neutrophil elastase, a serine protease, is normally located within azurophil granules of neutrophils and degrades Gramnegative bacteria and some other proteins such as coagulation proteins, growth factors, extracellular matrix proteins, immunoglobulins, and complement proteins, as well as PML-RAR[alpha] fusion protein [11].
There is a strong and specific association of WG with presence of anti-neutrophil cytoplasmic antibodies (ANCA) to a defined target antigen, proteinase 3 (PR3-ANCA), which is present within primary azurophil granules of neutrophils and lysozymes of monocytes (2).
Hypochlorous acid generated by the concerted activity of membrane-bound NADPH oxidase and azurophil granule myeloperoxidase of the neutrophil produces luminol chemiluminescence.
HNP1-3 are primarily stored in the azurophil granules of neutrophils and then released into circulation and infection sites in response to infectious pathogens [33].
Azurophil (or primary) granules are the first to be produced and contain MPO and a spectrum of neutrophil serine proteases (NSPs): cathepsin G (CG), neutrophil elastase (NE), proteinase 3 (PR3), and the recently discovered neutrophil serine protease-4 (NSP4) [30, 90].