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Isavuconazole is an intravenous and oral azole antifungal for the treatment of life-threatening invasive mould infections.
Infections with strains of Aspergillus fumigatus that are resistant to all azole antifungal medications have become common in western Europe and have been documented in other regions since 1998 (1,2), but until recently, had not been reported in the United States (3).
Azole antifungal resistance in Aspergillus fumigatus : 2008 and 2009.
The discovery of the azole antifungal compounds allowed for a broader spectrum of antifungal treatment and a shorter treatment duration [3].
Some studies have attributed resistance in Aspergillus partially to use of azole antifungal agents in agriculture.
Low doses of the drug caused perinatal death and skeletal defects in rats, similar to other azole antifungal agents.
Voriconazole, a recent azole antifungal acts by inhibiting the synthesis of ergosterol in the fungal membranes and ultimately the growth of the microrganism.
Purpose: The present study investigated the antifungal effect of 2',4,-dihydroxy-5'-(1'",1'"-dimethylallyl)- 8-prenylpinocembrin (8PP, formerly 6PP), a natural prenylflavonoid, on Candida albicans biofilms, and compared this with an azole antifungal (fluconazole) by studying the cellular stress and antioxidant response.
Two classes of systemic agents commonly are used for the treatment of onychomycosis: azole antifungal agents--specifically, the triazoles fluconazole and itraconazole--and an agent from the allylamine class, terbinafine.
Tinea corporis on a non-hair-bearing area is readily cleared with a topical azole antifungal agent, such as ketoconazole cream 2% twice daily for 2 weeks or a topical allylamine, such as terbinafine cream 1%, twice daily for 2 weeks.
Rhabdomyolysis has been reported with these drugs and the risk of this serious condition is increased with the use of macrolide antibiotics, such as Biaxin (clarithromycin) and azole antifungal agents, such as Diflucan (fluconazole).