azole


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Related to azole: azole antifungals, Echinocandins

pyr·role

(pir'ōl),
Divinylenimine; a heterocyclic compound found in many biologically important substances, for example, heme.
Synonym(s): azole, imidole

azole

(ăz′ōl′, ā′zōl′)
n.
Any of a class of organic compounds that have a five-membered heterocyclic ring with at least one nitrogen and two double bonds and that also may contain another heteroatom.

azole

Any of a family of broad-spectrum antifungals, including ketoconazole, fluconazole and itraconazole.
 
Indications
Blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and in sporotrichosis.
 
Adverse effects
Nausea, vomiting, anorexia, rash, pruritus, nonspecific increased liver enzymes, anaemia, leukopenia, thrombocytopenia, headache and others.
 
Drug interactions
Plasma levels of azoles are decreased by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin and rifampin.

azole

Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.

pyr·role

(pir'ōl)
A heterocyclic compound found in many biologically important substances.
Synonym(s): azole, imidole.
References in periodicals archive ?
Serious Hypersensitivity and Severe Skin Reactions , such as anaphylaxis or Stevens Johnson syndrome, have been reported during treatment with other azole antifungal agents.
guilliermondii strains exhibited high rates of azole resistance (Table 3), in agreement with the results of previous reports (13,33,34).
Moreover, the antifungal drugs available to successfully treat these infections are becoming increasingly limited, with polyenes, allylamines, azoles (e.
Random sampling of 20 retention data values from our observed assay samples produced a composite average value below the lower prediction bound only 6, 2, and 4 percent of the time for copper azole, micronized copper azole, and micronized copper azole (without the outlier), respectively (Table 3).
So when I have a moist macerated space, I like an azole.
22) Fungal keratitis responds well to treatment, especially with azoles and surgery should only be necessary in advanced cases.
As a general rule, the least biodegradable azole used at its lowest effective concentration is most desirable.
The most widely used replacements for CCA treatment are ACQ (alkaline copper quaternary compound), copper boron azole (CBA) and copper azole (CA-B) treatments.
Recent results suggest that growers should base Septoria control on an effective azole applied at robust doses in a two or three-spray programme, the main sprays being normally T1 or T2.
Fourteen patients also received courses of amphotericin B and/or azole therapy.
However, most contractors and architects have switched from CCA lumber to pressure-treated wood incorporating agents known as alkaline copper quaternary or copper boron azole.
Wood treated with less-toxic preservatives, such as ACQ, copper azole and ammoniacal copper citrate.