azole


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Related to azole: azole antifungals, Echinocandins

pyr·role

(pir'ōl),
Divinylenimine; a heterocyclic compound found in many biologically important substances, for example, heme.
Synonym(s): azole, imidole

azole

(ăz′ōl′, ā′zōl′)
n.
Any of a class of organic compounds that have a five-membered heterocyclic ring with at least one nitrogen and two double bonds and that also may contain another heteroatom.

azole

Any of a family of broad-spectrum antifungals, including ketoconazole, fluconazole and itraconazole.
 
Indications
Blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and in sporotrichosis.
 
Adverse effects
Nausea, vomiting, anorexia, rash, pruritus, nonspecific increased liver enzymes, anaemia, leukopenia, thrombocytopenia, headache and others.
 
Drug interactions
Plasma levels of azoles are decreased by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin and rifampin.

azole

Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.

pyr·role

(pir'ōl)
A heterocyclic compound found in many biologically important substances.
Synonym(s): azole, imidole.
References in periodicals archive ?
While the combination of azoles with amphotericin B has provided controversial results, (3) most of studies have found additive or synergistic effect when azoles were combined with terbinafine against C.
The solution strength for copper azole (CA) was based on previous tests.
In two cases, however, the combination of an azole plus terbinafine was successful.
The 2 main classes of antifungals are allylamines and azoles.
Proportionately more physicians from the Northeast than from other regions observed resistance to 1 or more azoles
Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure.
When hyperlipidemic patients have to take an azole for an extended period (eg, cancer prophylaxis or chronic osteomyelitis) and the azole is a strong CYP450 inhibitor (eg, itraconazole), switching to a statin that is not primarily metabolized by the CYP450 system (eg, pravastatin, pitavastatin) is wise.
Some studies have attributed resistance in Aspergillus partially to use of azole antifungal agents in agriculture.
The reality is that for, most clinicians, it has been well accepted for years that this drug has significant toxicities, probably the most among the azole class, especially in terms of liver issues and drug interactions being one of the most potent inhibitors of the hepatic CYP (cytochrome P450) system.
4 million pregnancies that occurred from 1997 to 2013, oral fluconazole increased the risk of spontaneous abortion from 7 to 22 weeks' gestation, compared with no exposure to fluconazole and with exposure to a topical azole.