azole


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Related to azole: azole antifungals, Echinocandins

pyr·role

(pir'ōl),
Divinylenimine; a heterocyclic compound found in many biologically important substances, for example, heme.
Synonym(s): azole, imidole

azole

(ăz′ōl′, ā′zōl′)
n.
Any of a class of organic compounds that have a five-membered heterocyclic ring with at least one nitrogen and two double bonds and that also may contain another heteroatom.

azole

Any of a family of broad-spectrum antifungals, including ketoconazole, fluconazole and itraconazole.
 
Indications
Blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and in sporotrichosis.
 
Adverse effects
Nausea, vomiting, anorexia, rash, pruritus, nonspecific increased liver enzymes, anaemia, leukopenia, thrombocytopenia, headache and others.
 
Drug interactions
Plasma levels of azoles are decreased by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin and rifampin.

azole

Infectious disease One of a family of synthetic broad-spectrum antifungal antibiotics–including ketoconazole, fluconazole, itraconazole Indications Various azoles have established efficacy in treating blastomyocosis, candidiasis, coccidioidomycosis, cryptococcosis, histoplasmosis, paracoccidoidomycosis and sporotrichosis Adverse effects N&V, anorexia, rash, pruritus, nonspecific ↑ liver enzymes, anemia, leukopenia, thrombocytopenia, headache, etc Drug interactions Plasma levels of azoles are ↓ by antacids, H2-receptor antagonists, sucralfate, isoniazid, phenytoin, rifampin. See Fluconazole, Itraconazole, Ketoconazole.

pyr·role

(pir'ōl)
A heterocyclic compound found in many biologically important substances.
Synonym(s): azole, imidole.
References in periodicals archive ?
auris, which is also found in the soil: Azoles have created an environment so hostile that the fungi are evolving, with resistant strains surviving.
Azole resistance in Aspergillus fumigatus in patients with cystic fibrosis: a matter of concern?
Half of these fungicides fell under the broad classification of azoles, and the remaining fungicides fell under the classes of strobins, anilides, and quinolines.
Ketoconazole and topical clotrimazole both belong to azole antifungal group which interferes with fungal cell wallergosterol synthesis by inhibiting cytochrome P450 enzyme.
Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles?
Another aspect regarding DDIs that is worth mentioning is the following: Besides the direct inhibition of catalytic activity that azole drugs exert on the CYP450 enzymes, especially CYP3A4, azole drugs also influence CYP3A4 and other CYP450 enzymes indirectly (32).
Por eso, la progresiva resistencia frente a las equinocandinas, asociada al incremento en su uso, la elevada incidencia de infecciones por Candida y la corresistencia a azoles y equinocandinas (25), ha generado la necesidad de estudiar los mecanismos de resistencia y buscar alternativas farmacologicas.
Isavuconazole is a new azole approved for aspergillosis and mucormycoses in adults in 2015.
The purpose of this study was to evaluate the in vitro fungicidal activity of RZF through analysis of time-kill kinetics for FLU-susceptible and FLU-resistant Candida species under conditions and at a pH relevant to the vaginal microenvironment, using the topical azole VVC therapeutic, terconazole (TER), as a comparator.
Ketoconazole is an imidazole derivative, meaning that there are 2 nitrogen atoms in the azole ring.
The potential of azole antifungals against latent/persistent tuberculosis.
Some studies suggested that the TR/L98H mutation acquired in the environment due to azole fungicides usage in agriculture.[sup][23],[24] We found that one itraconazole-resistant isolate harbored the TR34/L98H mutation was cross-resistance to both voriconazole and posaconazole.