auris, which is also found in the soil: Azoles
have created an environment so hostile that the fungi are evolving, with resistant strains surviving.
resistance in Aspergillus fumigatus in patients with cystic fibrosis: a matter of concern?
Half of these fungicides fell under the broad classification of azoles
, and the remaining fungicides fell under the classes of strobins, anilides, and quinolines.
Ketoconazole and topical clotrimazole both belong to azole
antifungal group which interferes with fungal cell wallergosterol synthesis by inhibiting cytochrome P450 enzyme.
resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles
Another aspect regarding DDIs that is worth mentioning is the following: Besides the direct inhibition of catalytic activity that azole
drugs exert on the CYP450 enzymes, especially CYP3A4, azole
drugs also influence CYP3A4 and other CYP450 enzymes indirectly (32).
Por eso, la progresiva resistencia frente a las equinocandinas, asociada al incremento en su uso, la elevada incidencia de infecciones por Candida y la corresistencia a azoles
y equinocandinas (25), ha generado la necesidad de estudiar los mecanismos de resistencia y buscar alternativas farmacologicas.
Isavuconazole is a new azole
approved for aspergillosis and mucormycoses in adults in 2015.
The purpose of this study was to evaluate the in vitro fungicidal activity of RZF through analysis of time-kill kinetics for FLU-susceptible and FLU-resistant Candida species under conditions and at a pH relevant to the vaginal microenvironment, using the topical azole
VVC therapeutic, terconazole (TER), as a comparator.
Ketoconazole is an imidazole derivative, meaning that there are 2 nitrogen atoms in the azole
The potential of azole
antifungals against latent/persistent tuberculosis.
Some studies suggested that the TR/L98H mutation acquired in the environment due to azole
fungicides usage in agriculture.[sup], We found that one itraconazole-resistant isolate harbored the TR34/L98H mutation was cross-resistance to both voriconazole and posaconazole.