Anxiolytics acting through agonist action at serotonin 1-A receptors.
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The five classes of drugs used most commonly for feline anxiety disorders are azapirones, benzodiazepines, monoamine oxidase inhibitors, tricyclic antidepressants, and selective serotonin reuptake inhibitors.
Azapirones stimulate serotonin receptors and block some adrenergic receptors.
(91,92) Currently, data are particularly scarce for the management of anxiety in patients with COPD, with inconclusive or contradictory findings reported for SSRIs, azapirones (including buspirone), and tricyclic antidepressants.
* Buspirone (Buspar) is the only drug available in the class called azapirones. It works via one of the serotonin receptors.
Tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and azapirones must be given continuously, and require several weeks to reach full effectiveness.
Azapirones: clinical uses of serotonin partial agonists.
Several studies have demonstrated that azapirones are effective in anxiety disorders.