Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy
Neuropathway mechanical lesions in the electrolytic model by direct target destruction or fimbria-fornix' transaction by pathway axotomy
can also be an option; nevertheless there are chances of unspecific results (Oliveira & Hodges, 2005).
Chromatolysis can be triggered by axotomy
, ischemia and toxicity to the cell, as well as cell exhaustion or virus infections leading to disintegration of Nissl substances.
In trigeminal neuralgia, hyper excitability of primary afferent neurons has been reported in several different trigeminal nerve injury and inflammation animal models, including chronic constriction nerve injury (CCI), axotomy
, and inflammatory models14.
Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy
following transient axonal stretch injury.
Levin, "Retinal ganglion cell axotomy
induces an increase in intracellular superoxide anion," Investigative Ophthalmology & Visual Science, vol.
However, several hours after axotomy
svh-2 expression is induced in the injured motor neurons.
Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy
2001) A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomy
3) Exogenous application of CNTF also support the survival of spinal motor neurons in vivo and preserves rats from axotomy
induced cell death.
In denervation induced by right leg sciatic nerve axotomy
, treatment with vitamin E reduced the increased level of MDA in gastrocnemius muscle in rats (Demiryurek and Babul, 2004).
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy