Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after
axotomy.
In denervation induced by right leg sciatic nerve
axotomy, treatment with vitamin E reduced the increased level of MDA in gastrocnemius muscle in rats (Demiryurek and Babul, 2004).
NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after
axotomy.
Quantitation of calcitonin gene-related peptide mRNA and Neuronal cell death in facial motor nuclei following
axotomy and 633 nm low power laser.
Researchers observed that VEGF-ZFP increases retinal ganglion cell survival after
axotomy and ischemia and promoted functional improvement of the pupillary light reflex after ischemia although treatment did not alter retinal vasculature.
They found that after
axotomy (via optic nerve transection), approximately 85% of all RGCs die within 14 days by apoptosis.
The study also included a sham-treated group and an
axotomy group (the L4 anterior primary ramus was transected).
Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells.
Sanger JR, Riley DA, et al: Effects of
axotomy on the cholinesterase and carbonic anhydrase activities of axons in the proximal and distal stumps of rabbit sciatic nerves: A temporal study.
Translational and rotational forces distort skull, brain and vessel architecture, producing, at the macroscopic level, contusions, lacerations and diffuse axonal injuries, including
axotomy following severe shear.
Testosterone-induced acceleration of recovery from facial paralysis following crush
axotomy of the facial nerve in male hamsters.
2000) reported that NGF may protect against degenerative changes in olfactory receptor neurons following
axotomy.
