The simplest idea is to base the 'coherent theory' on existing mathematical models (action potential, the pressure wave in the axoplasmic
fluid, and the mechanical wave in the surrounding biomembrane, see above) but introducing the coupling forces like it is done in continuum mechanics .
Rabies virions, introduced by animal bites or scratches, have an affinity for nicotinic acetylcholine receptors, where they replicate and reach the central nervous system by retrograde axoplasmic
transport, and then return to the periphery by intra-axonal transport to highly innervated extraneural sites.
The observed decrease in FA values may reflect the barriers to axoplasmic
transport, the local accumulation of apoptosis in organelles, and secondary Wallerian degeneration in the WM, while the increased MD values may be the result of vasogenic edema.
Role of axoplasmic
transport in the pathophysiology of ischaemic disc swelling.
The central projection of chemoreceptor axons in the crayfish revealed by axoplasmic
These represent accumulations of neuronal organelles (chiefly mitochondria) in areas where neuronal axoplasmic
flow has been affected by losal ischaemia.
The neurofilament proteins are found in neurons and assemble to form intermediate filaments that regulate axon growth, axoplasmic
transport, and axon caliber (Capano et al.
7,8) Methotrexate-induced disruption of anterograde axoplasmic
flow may cause axonal accumulation of [beta]-APP, a constituent neuronal transmembrane glycoprotein.
The pathogenesis of neuropathy is explained by structural changes in the microtubules of peripheral nerves and interference with axoplasmic
When there is high pressure of the CSF, the pressure extends around the optic nerve and results in obstruction of the axoplasmic
flow in the optic nerve axons.
The central projections of chemoreceptor axons in the crayfish revealed by axoplasmic
Even though the pathogenesis remains obscure, it is thought that alteration in the axoplasmic
flow of ganglion cells is the possible underlying reason.