Myelin layers were blurred; degenerated myelin lamellae and swelling axoplasm
The pressure wave in the axoplasm
is governed by a 1D Navier-Stokes model:
A, Normal, uninjured nerve with fibers showing preserved axoplasm
, mitochondrial profiles (arrowheads), and astrocytic septa (arrow).
The nerve terminals from nerve-muscle preparations showed changes in the distribution of subcellular organelles, axoplasm
becomes more electron dense and there was pronounced mitochondrial swelling.
The movement of the axon's entire contents (the axoplasm
) within the membrane is characterized as slow transport.
In addition to ultrastructural changes, as swollen thinned myelin sheath and myelin splitting, besides degeneration of axoplasm
. This study demonstrated the histological, immunohistochemical and ultrastructure effects of compressed spinal cord injury in rats, only at the site of the lesion, without treatment or assessment of locomotor functions.
A nerve pulse is actually an action potential which is transmitted down the axoplasm
core of a nerve fibre.
enriched in a protein mobilized by nerve injury induces memory-like alterations in Aplysia neurons.
When a peripheral nerve is sectioned, Wallerian degeneration occurs in the distal stump, where the axon disintegrates by proteolytic action of enzymes present in the axoplasm
. Macropages participate phagocytosing both the axon and Schwann cells, thus they prevent clogging in the next regeneration of the axon and synthesize the nerve growth factors (Stoll et al., 1989; Tumble, 2000).
Fortunately, the stellate ganglion of the squid giant fiber system, which shares many neuronal properties with mammalian systems, including a robust NF metabolism, is readily separated into giant cell bodies and pure axoplasm
in quantities sufficient for diverse biochemical studies.
The fine structure demonstrated that in the axoplasm
were noted the presence of neurofilaments, mitochondria and microtubules.
Mid-size squid organelles 0.2-0.53 [micro]m in diameter are transported in axoplasm
at average velocities of 1.1 [micro]m/s, whereas larger particles (>0.5 [micro]m diameter), mostly mitochondria, move more slowly (0.2 [micro]m/s).