axonopathy

[ak″sŏ-nop´ah-the]

a disorder disrupting the normal functioning of the axons.

ax·o·nop·a·thy

(aks'on-op'a-thē),

A disorder affecting primarily the axons of peripheral nerve fibers (although secondary demyelination occurs), in contrast to one affecting only myelin (myelinopathy).

axonopathy

/axo·nop·a·thy/ (ak″sah-nop´ah-the) a disorder disrupting the normal functioning of the axons; in distal a. the disease progresses from the center toward the periphery and in proximal a. the disease progresses from the periphery toward the center.

axonopathy

a disease of axons.

Boxer progressive axonopathy

an inherited, degenerative disorder of the peripheral and central nervous system in Boxer dogs. By 6 months of age, dogs homozygous for the trait show ataxia and weakness in the hindlimbs and an absence of the patellar reflex.

congenital axonopathy

Holstein-Friesian calves are recumbent from birth; the necropsy lesion is degeneration in spinal cord and midbrain nerve tracts; considered to be inherited as an autosomal recessive trait.

inherited ovine degenerative axonopathy

inherited in several forms in some sheep breeds (Suffolk, Merino, Coopworth); may be congenital or develop at up to 6 months old; signs include ataxia, recumbency, invariable death. Probably the same disease as that called Murrurrundi disease.

peripheral and central distal axonopathy of Birman cats

see distal polyneuropathy of Birman cats.

segmental axonopathy

axonopathy affecting a segment of the axons.

References in periodicals archive ?

1-3) The electrophysiological examination including both nerve conduction and electromyography studies should identify peripheral nerve dysfunction if present, along with the specific location in the nerve pathway, involvement of sensory and/or motor axons, and the presence of myelinopathy and/or axonopathy neuropathic process.

GEHS Neurophysiological Classification System for Patients with Neuropathy of the Ulnar Nerve at the Elbow

Hereditary spastic paraplegia (HSP) includes a large and diverse group of genetic disorders whose main feature is progressive spasticity and weakness in the lower limbs, as a result of continuous distal axonopathy caused by defects in the mechanisms that transport proteins and substances along the axons [90, 91].

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

The findings on nerve conduction studies were in keeping with a sensorimotor axonopathy.

Encephalopathy caused by thiamine deficiency

The most common form of DN is a length-dependant symmetrical distal axonopathy that may be relentlessly progressive or may remain stable for years.

Radiology and Diabetes Mellitus

Imaging studies show the virus attacking at the anterior horns of the spinal cord; nerve conduction studies show a motor axonopathy, but without much demyelination.

Dengue, west nile finding homes in United States

9] Bansal et al (2006) have suggested that the slowing of NCV indicates the ongoing damage to the myelin sheaths and they are also of the opinion that the amplitude decreases with the rising HbA1c levels, thus suggesting the onset of axonopathy.

Early diagnosis of neuropathy in diabetic patients using nerve conduction studies

An infant with Marfanoid phenotype and congenital contractures associated with ocular and cardiovascular anomalies, cerebral white matter hypoplasia and spinal axonopathy.

Marfan syndrome: new mutations of the FBN1 gene/Sindrome de Marfan, mutaciones nuevas y modificadoras del gen FBN1

Disease Pathology Inheritance Genes/chromosomal name (a) mode loci associated with disease, n CMT1 Abnormal myelin AD (b) 9 CMT2 Axonopathy AD 19 CMT4 Either myelinopathy AR 10 or axonopathy CMTX Axonopathy with XLD 2 secondary myelin changes Disease Proportion name (a) of all CMT, % CMT1 40-50 CMT2 10-15 CMT4 Rare CMTX 10-15 (a) Intermediate dominant (dominant inheritance with NCV between demylinating and axonopathic) and other rare forms are not included.

Increased serum creatine kinase

2002) Tau and axonopathy in neurodegenerative disorders.

Metabolism of amyloid [beta] peptide and pathogenesis of Alzheimer's disease

2] Organophosphate induced delayed polyneuropathy (OPIDP), a sensory-motor distal axonopathy, usually occurs 1-4 weeks after single or short-term exposures and it may be progressive and severe.

Organophosphate induced delayed polyneuropathy: an unusual presentation

ACR Neurotoxicity: Evolving Neurobiological Concepts of the Distal Axonopathy

Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry

With hind limbs hyperflexion and a abnormal gait because of distal axonopathy with skeletal muscle denervation and atrophy.