axonal transport


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.

axonal transport

The process by which neurones move substances from the cell body down the axon, and from the end of the axon back to the cell body.

Transport down the axon is necessary because axons cannot synthesise proteins; transport to the cell body recycles substances and carries signals by axon terminals and trophic factors to the cell body where they affect cellular processes.

axonal transport

The active (energy-dependent) process by which proteins and organelles are moved inside an axon.
Synonym: axoplasmic transport
See also: transport
Mentioned in ?
References in periodicals archive ?
Because HDAC6 is involved in cytoskeletal formation, modulation of cellular oxidation/reduction state, and the ubiquitin-proteasome system, inhibition of HDAC6 improves pathological conditions in neurons such as impairments in axonal transport, oxidative stress, and protein aggresome formation in vitro [18, 19].
Mechanisms of the inhibition of fast axonal transport by local anesthetics.
Therefore, it stands to reason that the integrity of the microtubule transport system is crucial for axonal transport [129].
We hypothesized that the axonal transport of substances in old and young rats is unlike to the axonal transport in adult rats.
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport. Hum.
Small quantities of botulinum toxin can undergo retrograde axonal transport to the central nervous system, but there is no evidence that this has any effect on humans.
* Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.
Subcellular structure, axonal transport mechanisms and the structural basis of electrical and chemical signalling are described concisely.
KIF5A helps to move key proteins and organelles specialized parts of cells -- up and down that axonal transport system, controlling the engines for the nervous systems long-range cargo trucks.
showed that axonal transport and presynaptic release of TDP-43 could potentially be a route of transmitting TDP-43 to the postsynaptic cells [80].
The transport of the administered drug into extradural or subarachnoid space either by diffusion or by the centripetal axonal transport results in central action.