axonal transport


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axonal transport

The process by which neurones move substances from the cell body down the axon, and from the end of the axon back to the cell body.

Transport down the axon is necessary because axons cannot synthesise proteins; transport to the cell body recycles substances and carries signals by axon terminals and trophic factors to the cell body where they affect cellular processes.

axonal transport

The active (energy-dependent) process by which proteins and organelles are moved inside an axon.
Synonym: axoplasmic transport
See also: transport
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References in periodicals archive ?
Hollenbeck, "The axonal transport of mitochondria," Journal of Cell Science, vol.
In this context, one of the most studied genes is paraplegin (SPG7), a mitochondrial metalloprotease belonging to the family of ATPases associated with diverse cellular activities (AAA) [96, 97], whose mutations result in mitochondrial dysfunction of muscle tissue and mitochondrial-dependent impairment of axonal transport [98, 99].
Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats.
We wondered whether this striking rescue might be caused, at least in part, by improvements in axonal transport," explained Dr.
Axonal transport of mitochondria to synapses depends on Milton, a novel Drosophila protein.
Uptake and retrograde axonal transport of various exogenous macromolecules in normal and crushed hypoglossal nerves.
The results demonstrate that the axonal transport of cargo proteins is impaired in preclinical models of ALS and Parkinson's disease and correlates with disease severity.
INTRODUCTION: Location of motor neuron somata supplying forelimb muscles have been studied by retrograde cell degeneration technique [5],[6],[7],[8],[9] and [10] by electrophysiological method [1] and by retrograde axonal transport of horse radish peroxidase (HRP) [11],[12],[13],[2] and [14] These studies have shown the locations of motor neuron somata of major forelimb nerves in cervical enlargement of spinal cord.
The central importance of protein synthesis and axonal transport during Aplysia long-term synaptic facilitation is examined by Guan and Clark.
12) evaluation of retrograde axonal transport of toxins to the spinal motor neurons and their response (access and possible uptake of toxic substances at the neuromuscular junction).
KineMed's techniques have also been applied to investigate other pathways such as microtubule dynamics, mitochondrial turnover and axonal transport which are involved in HD and other neurodegenerative diseases.