Disarm Therapeutics is a biotechnology company that is creating a new class of disease-modifying therapeutics for patients with axonal degeneration
, a central driver of neurological disease-causing disability and disease progression.
in multiple sclerosis: can we predict and prevent permanent disability?
Nevertheless, the findings described in our case included nerve fiber vacuolation and axonal degeneration
. In the present case, the atrophy of the axial and appendicular skeletal striated musculature and the presence of anguloid myofibers without inflammatory infiltrate suggested a neurogenic origin (GRAESSER et al., 2006; DIAZ-DELGADO et al., 2018).
Salter et al., "Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration
in multiple sclerosis," Archives of Neurology, vol.
Misgeld, "In vivo imaging of axonal degeneration
and regeneration in the injured spinal cord," Nature Medicine, vol.
In the early periods of an axonal degeneration
, motor unit axonal potential (MUAP) morphology remains normal.
From autopsy findings in acute demyelinating disease, the spinal cord and optic chiasm reveal patches of demyelination and axonal degeneration
associated with necrosis and cavitation.
T2 signal is one parameter commonly used to assess nerve damage since increased intensity may reflect axonal degeneration
and the presence of fluid within the fascicles and the interstitium .
Milbrandt, "Amyloid precursor protein cleavagedependent and -independent axonal degeneration
programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway," The Journal of Neuroscience, vol.
The optic nerve crush model has elucidated the role of calcium in axonal degeneration
. Axotomy in rat models breaks neuronal membranes and may open voltage-gated calcium channels, allowing the influx of extracellular calcium and the initiation of degeneration .
(5) These deposits encroach upon the nerve fibers resulting in axonal degeneration
and segmental demyelination.
Here, we provided morphological evidence that exogenous administration of a specific calpain inhibitor delays WD-induced axonal degeneration
of optic nerve fibers for up to 4 days.