axonal degeneration

(redirected from axon degeneration)

ax·o·nal de·gen·er·a·tion

a type of peripheral nerve fiber response to insult, wherein axon death and subsequent breakdown occur, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibers; often referred to as wallerian degeneration.
Synonym(s): axon degeneration
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
In the process of axon degeneration, known as Wallerian degeneration, activated Schwann cells release cytokines and chemokines, which recruit the macrophages at the injury sites [3].
Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin.
This model has the advantage of avoiding overt damage to ocular structures, which will cause inflammatory responses, while it can effectively induce RGCs and axon degeneration that simulates the progression of glaucoma.[sup][9]
He supported the hypothesis that inflammation is necessary for new lesion formation and conditions causing axon degeneration and therefore early, more efficacious treatment of inflammation with more potent immunomodulatory agents such as alemtuzumab, may inhibit the establishment of immunological chronicity and may protect the CNS from degeneration.
The articles discuss research of the UPS in connection with the development and diseases of the nervous system and include such topics as the UPS in axon degeneration, the UPS in pain transmission and neuropathic pain, ubiquitin- dependent proteolysis in Parkinson's disease, ubiquitin domain proteins, and the functional role of proteasome antibodies in neurological disorders.
This finding may hold more promise for injuries or early demyelination, in which axon degeneration has yet occurred.
Examining the brains of young dogs, Siegel and his coworkers found three regions in which narcoleptic dogs showed much more axon degeneration than do normal dogs.