cafe au lait spots

(redirected from axillary freckling)

ca·fé au lait spots

pigmented cutaneous lesions, ranging from light to dark brown, and due to an excess of melanosomes in the malpighian cells, rather than to an excess of melanocytes; café au lait spots are one of the major cutaneous manifestations of neurofibromatosis (von Recklinghausen disease); six or more café au lait spots, some exceeding 1.5 cm in diameter, can almost always be found in type 1 (peripheral) neurofibromatosis. These are often accompanied by frecklelike spots in the axilla.

ca·fé au lait spots

(kăf-ā-ō-lā spotz)
Pigmented cutaneous lesions, ranging from light to dark brown; due to an excess of melanosomes in the malpighian cells, rather than to an excess of melanocytes.

cafe au lait spots

Milk coffee-coloured oval patches, from one to 15cm or more long, on the skin. If more than five of these occur in childhood, and especially if they extend into the armpit, it is likely that the condition of NEUROFIBROMATOSIS (Recklinghausen's disease) is developing.
References in periodicals archive ?
Melanocytic hamartomas of the iris (Lisch nodules), axillary freckling (Crowe's sign), or multiple cutaneous neurofibromas serve as additional clues to neurofibromatosis.
It is characterized by cutaneous findings, most notably cafe-au-lait spots and axillary freckling, osseous dysplasia, and benign and malignant nervous system tumors, and neurofibromas in particular.
Axillary freckling as a diagnostic aid in neurofibromatosis.
Examination of the sibling also revealed cafe-au-lit spots and axillary freckling.
On the other hand, neurofibromatosis (NF) is a common genodermatosis of autosomal dominant variant with an incidence of 1 in 3000 births.1 NF can be diagnosed clinically by the presence of cafACopyright-au-lait macules, cutaneous and subcutaneous nodules, axillary freckling and peripheral nerve enlargement.
The skin examination revealed multiple papilloma lesions of 0.5 to 5 centimeters in diameter located on the anterior and posterior thorax, abdomen and upper limbs that were interpreted as neurofibromas, along with cafe-au-lait spots and axillary freckling (Figure 1).
Axillary freckling, cafe-au-lait macules, plexiform neurofibromas or any other skeletal deformities were not present.
2007;39:1120-6) at the Catholic University of Leuven (Belgium), the hallmarks of Legius syndrome include multiple cafe au lait macules, axillary freckling, and autosomal dominant transmission, all of which are also among the NF1 diagnostic criteria established by the National Institutes of Health (JAMA 1997;278:51-7).
The disease can manifest as one of several types of lesions, including cafe au lair spots, cutaneous tumors, plexiform lesions, axillary freckling, Lisch nodules of the iris, optic gliomas, and bony abnormalities.
"Typically the next feature is axillary freckling, which is usually evident in the school-age child.
Children with neurofibromatosis type 1 may demonstrate Crowe's sign (axillary freckling); but their plexiform neuromas, if present, may contain significantly more pigment than lesions pictured in textbooks.
(3) NF1 is characterized by multiple cafe-au-lait macules, axillary freckling, neurofibromas, and Lisch nodules (pigmented iris hamartomas).