avidin


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av·i·din

(av'i-din),
A glycoprotein, obtained from egg whites, that possesses a high affinity for biotin. Labeled avidin is allowed to bind to biotin-tagged antibodies to amplify antigen-antibody reactions that may be difficult to visualize. Ingestion of avidin can cause a biotin deficiency.
Synonym(s): antibiotin
[L. avidus, eager fr. aveo, to crave + -in]

avidin

(ăv′ĭ-dĭn)
n.
A protein found in uncooked egg white that binds to and inactivates biotin.

avidin

a glycoprotein in raw egg white that interacts with biotin to make it unavailable to the body. Cooking destroys avidin.

avidin

A 68-kD tetrameric glycoprotein found in egg white which has a high affinity for biotin, an association used in immunology for the avidin-biotinylated immunoperoxidase method. When eggs are eaten in excess, avidin-biotin avidity may cause biotin deficiency.

av·i·din

(av'i-din)
Glycoprotein obtained from egg whites that possesses a high affinity for biotin; ingestion can cause biotin deficiency.
[L. avidus, eager fr. aveo, to crave + -in]

avidin (av´idin),

n a glycoprotein in nondenatured egg whites (raw) that binds biotin and prevents its absorption, causing biotin depletion.

avidin

a constituent of normal eggs which inhibits the absorption of biotin. The feeding of large quantities of raw egg whites causes dermatitis, alopecia and cracked hooves in pigs and heavy mortality in mink.
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References in periodicals archive ?
When kernels of avidin corn were infested with Angoumois grain moths or maize weevils, most of the larvae died inside kernels that contained at least 20 parts per million of avidin.
Avidin
This was followed by incubation with HRP-conjugated avidin for 30 min (250 ng/mL) and with o-phenylenediamine as a chromogenic substrate for additional 20 min.
Environmentally relevant metal and transition metal ions enhance Fc[epsilon]RI-mediated mast cell activation. (Research)
Avidin, FITC-labeled biotin (FITC-biotin), and FITC-conjugated streptavidin (FITC-streptavidin) were obtained from Sigma-Aldrich.
Visual recognition and efficient isolation of apoptotic cells with fluorescent-magnetic-biotargeting multifunctional nanospheres
Gold NPs, 15 nm in diameter, and avidin were provided by SABC.
Ultrasensitive densitometry detection of cytokines with nanoparticle-modified aptamers
4; the antibodies attach to the avidin in the exposed regions.
High-speed interferometric detection of label-free immunoassays on the biological compact disc
5%) supplemented with avidin solution (Avidin/Biotin Blocking Kit, Vector) was used to block tissue sections for 30 minutes.
Increased apoptosis in infiltrating mononuclear cells of colorectal cancer: a mechanism for tumor escape
To facilitate conjugation with avidin to detect biotinylated targets, QDs have been modified with dihydrolipoic acid (3).
Nanodiagnostics: a new frontier for clinical laboratory medicine
The reactivity could be weakened by pretreatment with avidin and biotin.
Immunohistochemical expression of galectin-3 in benign and malignant thyroid lesions
In conventional pretargeting, the patient is first injected with a targeting protein, such as an antibody, which is linked to biotin or avidin molecules that have a strong affinity for each other.
Patent issues to Immunomedics for improved methods of detection and therapy; Novel "pretargeting" methods developed for cancer, infectious and cardiovascular diseases
Biotin-labeled DNA was detected by use of avidin-conjugated fluorescein isothiocyanate (FITC; Vector) and biotin-conjugated avidin (Vector).
Investigation of the genomic representation of plasma DNA in pregnant women by comparative genomic hybridization analysis: a feasibility study
A general procedure for optimizing concentrations of capture antibody, biotinylated detecting antibody, and enzyme-labeled avidin in ELISAs-application to assays for [alpha]-fetoprotein, prolactin, FSH and LH in serum.
Sensitive automated ELISA for measurement of vitamin D-binding protein (Gc) in human urine
The in vivo-biotinylated anti-CEA scFv was purified from bacterial lysates by monovalent avidin chromatography and used to establish an immunofluorometric assay for CEA in streptavidincoated microplates.
Use of an in vivo biotinylated single-chain antibody as capture reagent in an immunometric assay to decrease the incidence of interference from heterophilic antibodies

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