AVERT

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AVERT

Cardiology Atorvastatin VErsus Revascularization Treatments. A trial comparing the efficacy of aggressive lowering of cholesterol in patients at risk of future cardiovascular events (ischaemic heart disease and stable angina) to percutaneous coronary intervention.
Conclusion Atorvastatin evoked a 46% reduction in LDL-C compared to an 18% reduction with revascularization; ischaemic events were 36% lower with atorvastatin than with revascularisation; the first ischaemic event occurred after a much longer time in atorvastatin patients. Aggressive LDL-C lowering in patients with stable CAD results in a markedly reduced risk of cardiovascular events (nonfatal heart attack, bypass surgery, revascularization, and worsening angina) compared with patients receiving angioplasty followed by usual care. In AVERT, 13% of patients treated with atorvastatin suffered a cardiovascular event compared with 21% of patients receiving angioplasty and usual care.
Cardiovascular surgery Artificial Valve Endocarditis Reduction Trial. A trial comparing the St. Jude masters series valve with silver (Silzone) coated sewing cuff with the St Judes mechanical heart valve with uncoated cuff
Logistics Randomised, multicenter.
Conclusion Trial was stopped in 2000, when 807 patients had been randomised, because of an increased risk of major paravalvular leak leading to valve explant in the Silzone arm of the study.

AVERT

Cardiology
1. A clinical trial—Atorvastatin Versus Revascularization Treatments–which evaluated the efficacy of aggressive lowering of cholesterol in Pts at risk of future cardiovascular events.
2. A clinical trial–Artificial Valve Endocarditis Reduction Trial.
References in periodicals archive ?
(135) Here, again, NQF chose an event that met the same three key characteristics--the event is avoidable; the result of a medical error; and is avertable through the adoption of simple guidelines.
In other words, whereas NQF chose conditions that were avoidable, the result of hospital mistakes, and avertable through the adoption of simple guidelines; CMS chose a condition that is common, unavoidable and the often, contracted despite proper hospital care.
Cigarette smoking is an avertable cause of peri-operative respiratory complications, wound infection, myocardial infarction, stroke, and mortality.
The report concluded that avertable deaths were relatively common, and improvements of accessibility of healthcare had a measurable impact during the 1980s.
Adding a new vaccine to a national immunisation programme requires consideration of the avertable burden, relative value of the vaccine compared with alternative uses of resources, affordability, likelihood of public acceptability and political support for a vaccine against a sexually transmitted disease, and feasibility of achieving high coverage in young adolescent girls.
From a worldwide perspective, countries with the highest risk of cancer account for less than one-third of the projected avertable deaths, highlighting why a regional universal vaccination approach will be most effective in reducing the overall global burden.