auxotroph


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auxotroph

 [awk´so-trōf]
an auxotrophic organism.

aux·o·troph

(awk'sō-trōf),
A mutant microorganism that requires some nutrient that is not normally required by the organism (prototroph) from which the mutant was derived. Compare: polyauxotroph, monoauxotroph.
[auxo- + G. trophē, nourishment]

auxotroph

(ôk′sə-trŏf, -trōf′)
n.
An organism, such as a strain of bacteria, that has lost the ability to synthesize certain substances required for its growth and metabolism as the result of mutational changes.

aux·o·troph

(awk'sō-trōf)
A mutant microorganism that requires some nutrient that is not required by the organism (prototroph) from which the mutant was derived.
[auxo- + G. trophē, nourishment]

auxotroph

a mutant strain of a microorganism that requires growth factors, for example AMINO ACIDS, in addition to those required by the WILD TYPE and therefore will not grow on MINIMAL MEDIUM which will support the growth of the wild type.
References in periodicals archive ?
pseudomallei 82 (a purine auxotroph) required longer incubation (5 d) before a turbidity increase was evident.
Li et al., "Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium," Proceedings of the National Academy of Sciences of the United States of America, vol.
Nakamaya [16] cultured Brevibacterium and Corynebacterium auxotrophs on 20-40oC and reported maximum lysine production 17- 39g/L at 30oC that is also in support of our optimized temperature.
The present study focused on the development of auxotroph and over production of lysine in stirred tank fermentation, after releasing the various metabolic control mechanism and utilizing three different media.
Differential expression of Met auxotroph, Escherichia coli DL41 (DE3) pCOCK, has revealed proteomic variation in cells forced to use TeMet in the translation of proteins.
For example, auxotroph mutants are easy to maintain and observe on selective media and are strongly selected against on restrictive media (Welden & Hossler, 2003; Krist & Showsh, 2007).
The yeast morphotype but not the mold, for example, has a cysteine dioxygenase activity and is a cysteine auxotroph. To begin studies on the role of sulfur metabolism in dimorphism, we are isolating genes important in the central sulfur metabolic pathway.
coli NK3, a cysteine auxotroph. This mutant lacks the gene for OAS-TL and therefore cannot grow in medium without supplemental cysteine.
When a polyamine auxotroph is grown under conditions of polyamine starvation, cadaverine is present in the perchloric acid-extractable pool.
Paradoxically, single and double auxotroph strains had lower mean MICs than the 2 nonauxotroph strains.
As a result, a conditional promoter strategy driving the expression of AroB (chorismate synthase) was used to obtain aromatic amino acid auxotroph strain, which was unable to grow in medium containing the three aromatic amino acids and displayed attenuated virulence in pulmonary and systemic murine infection models.