Though Western researchers reported autosplenectomy
as a frequent phenomenon in sickle cell anaemia patients, persistence of spleen is more commonly encountered in Indian scenario.
3%) patients were treated conservatively, one patient who was also having thalassemia trait ended up in autosplenectomy
05]--which may be due to loss of splenic platelet pool function in adult sickle cell patients consequent upon autosplenectomy
It was concluded by this study that thrombocytosis or even correction of thrombocytopenia in patients with SLE should raise suspicion of hyposplenism or autosplenectomy, in particular if secondary APS is present.
Thrombocytosis in systemic lupus erythematosus: a possible clue to autosplenectomy.
Therefore hydroxyurea treatment should be initiated in infancy to prevent chronic endothelial damage induced end-organ insufficiencies including autosplenectomy
to relieve permanent inflammatory process all over the body to decrease frequency of hospitalizations and eventually to restore immunity against infectious agents.
The objective of this study was to determine and review the prevalence of autosplenectomy among patients with sickle cell anemia in a tertiary healthcare facility.
Autosplenectomy was defined as the non visualization of the spleen; while Splenomegaly was defined when the long axis of the organ is longer than 130 mm.
4%) of the study subjects had autosplenectomy as determined by non-visualization of the spleen during ultrasonographic examination.
The thrombocytosis could result from autosplenectomy
, as the spleen could pool between 20-40% of the total body platelets  that become available in the circulation when the spleen is nonfunctional.
Children with homozygous SCD (SS) achieve complete splenic dysfunction by age 5 years when the spleen is replaced by fibrotic tissue -- a process called autosplenectomy (Lane, 1996).
Children with HbSS generally experience splenic sequestration between the ages of 6 months and 3 years before autosplenectomy, while children with the heterozygous forms of SCD (SC & S[Beta] thalassemias) who do not undergo autosplenectomy have problems with splenic sequestration continuing into late childhood.