autosomal dominant polycystic kidney disease


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autosomal dominant polycystic kidney disease

A common (1:400–1:1000) autosomal dominant condition (OMIM:173910), which causes 6–9% of end-stage renal disease in developed countries. ADPKD first appears in adults with upper quadrant tenderness; extrarenal disease is due to defective extracellular matrix, with hepatic cysts, diverticulosis, berry and abdominal aneurysms, annuloaortic ectasia and valvular regurgitation.

Clinical findings
Acute or subacute onset of azotaemia and hypertension, due to increased activity of the renin-angiotensin-aldosterone (RAA) system, possibly related to the ischaemic pressure induced by the expanding cysts.

Lab
Anaemia, increased ESR, increased WBCs.
 
Diagnosis
Ultrasonography.

autosomal dominant polycystic kidney disease

ADPKD A common–1:400-1:1000 AD condition, which causes 6-9% of ESRD in developed countries Clinical Acute or subacute onset of azotemia and HTN, due to ↑ activity of the RAA system, possibly related to the ischemic pressure induced by the expanding cysts; ADPKD first appears in adults with upper quadrant tenderness; extrarenal disease is due to defective extracellular matrix, with hepatic cysts, diverticulosis, berry and abdominal aneurysms, annuloaortic ectasia, valvular regurgitation, anemia, ↑ ESR, ↑ WBCs Diagnosis Ultrasonography. See Polycystic kidneys.
References in periodicals archive ?
A case of severe aortic valve regurgitation caused by an ascending aortic aneurysm in a young patient with autosomal dominant polycystic kidney disease and normal renal function.
Abdominal aortic aneurysms and autosomal dominant polycystic kidney disease.
Sirolimus and kidney growth in autosomal dominant polycystic kidney disease.
Torres VE, Harris PC, Pirson Y Autosomal dominant polycystic kidney disease.
Explain how the FNP PCP can educate and empower patients during their treatment of autosomal dominant polycystic kidney disease.
Autosomal dominant polycystic kidney disease (ADPKD) affects approximately 500,000 people in the United States and is the most frequent genetic cause of renal failure in adults, accounting for 10% of patients on dialysis in the U.
Autosomal dominant polycystic kidney disease is among the most prevalent dominant human disorders, affecting between 1 and 1000 and 1 and 3000 individuals worldwide.
Urinary excretion of monocyte chemoattractant protein-1 in autosomal dominant polycystic kidney disease.
Review of literature on reported cases of Caroli's disease associated with autosomal dominant polycystic kidney disease [Table omitted]
Autosomal dominant polycystic kidney disease is one of the most common hereditary disorders affecting 1 in 600 to 1 in 1000 individuals.
Autosomal dominant polycystic kidney disease in the neonatal period: association with a cerebral arteriovenous malformation.
of Legacy Good Samaritan Hospital & Medical Center in Portland, stated: "We are very pleased to be initiating this trial in patients with autosomal dominant polycystic kidney disease.

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