Predominant Th1 and Th17 cytokine production are characteristic of many organ-specific autoimmune diseases, and the dysregulation of p38 MAPK activity specifically in autoreactive lymphocytes
appears to enhance IL-17 and IFN-[gamma] expression [66, 70-72].
These include not only the basic maturation and distribution of immune cell types and selection against autoreactive lymphocytes
but also changes designed specifically to protect the pregnancy against immunemediated miscarriage.
Tike other biological systems, the mechanisms of the recessive tolerance are not 100% effective, and a part of autoreactive lymphocytes
escape their demise and enter the periphery, the secondary lymphoid organs.