autoreactive lymphocyte


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autoreactive lymphocyte

A lymphocyte that reacts with autoantigens. Most of these cells are eliminated during lymphocyte maturation or by activation-induced cell death.
Synonym: self-reactive lymphocyte
See also: lymphocyte
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Predominant Th1 and Th17 cytokine production are characteristic of many organ-specific autoimmune diseases, and the dysregulation of p38 MAPK activity specifically in autoreactive lymphocytes appears to enhance IL-17 and IFN-[gamma] expression [66, 70-72].
These include not only the basic maturation and distribution of immune cell types and selection against autoreactive lymphocytes but also changes designed specifically to protect the pregnancy against immunemediated miscarriage.
Tike other biological systems, the mechanisms of the recessive tolerance are not 100% effective, and a part of autoreactive lymphocytes escape their demise and enter the periphery, the secondary lymphoid organs.