The major pathogenic process of MS mainly starts with the activation of autoreactive
lymphocytes and their migration across the blood-brain barrier.
2008) Sites and stages of autoreactive
B cell activation and regulation.
We used autologous serum therapy in place of autohemotherapy as the circulating autoreactive
factor is present in the serum, not in the cellular components of blood.
20] This control on B cell activation and proliferation may be clinically important in autoimmune diseases as autoreactive
antibodies produced by B-cells play a major role in the pathophysiology of autoimmunity.
By binding BLyS, Benlysta inhibits the survival of B cells, including autoreactive
B cells, and reduces the differentiation of B cells into immunoglobulin-producing plasma cells, according to the company.
The "Re:Mission" phase IV trial results showed that 67% of patients with functional, autoreactive
NK cells remained relapse-free for a pre-scheduled follow-up of 2 years vs.
Type 1 diabetes is an autoimmune disease characterized by the destruction of islets by autoreactive
T cells, which mistakenly attack islets as if they were an infection.
CD4+ LKM-specific and anticlonotypic T-cell responses in LKM-1 antibody-positive autoimmune hepatitis.
The predominant autoreactive
epitopes are in its C-terminal region and are oriented intracellularly in a way that is consistent with a sequestered autoantigen.
Prolactin, systemic lupus erythematosus and autoreactive
B Cells: lessons learnt from murine models.
Alopecia areata is mediated by autoreactive
NKG2D+ CD8+ T cells.
The above mentioned factors act either independently or jointly on the immune system, triggering the production of autoreactive
B lymphocytes or abnormal types of activated T lymphocytes and of antigen presenting cells, with the consequent manufacture of auto-antibodies, immune complexes and cytokines, all these elements leading to installation of inflammation and, subsequently, of specific organ lesions [13-15].