DCC-3116, discovered using the company's novel switch control inhibitor platform, is designed to inhibit autophagy
by inhibiting the ULK kinase.
Given that the molecular machinery of autophagy
is highly conserved in mammals, autophagy-mediated protein degradation could contribute to muscle growth in meat animals.
Then, we evaluated how curcumin performed its role via influencing autophagy
pathway and proinflammatory cytokine expression.
Acute treadmill exercise has been shown to induce autophagy
in skeletal muscle.
The work, which appeared in the journal Nature on January 23, 2019, reveals autophagy
to be a completely novel tumor-suppressing pathway and suggests that treatments to block the process in an effort to curb cancer may unintentionally promote it very early on.
We investigated mitochondrial autophagy
and the NLRP3 inflammasome in the pulmonary system of NOD/SCID mice for 48 h after CPR.
Mercer and her colleagues demonstrated that mitochondrial complex I also plays a key role in triggering and increasing autophagy
and regulating its duration.
, also referred to as type 2 programmed cell death, is the process of transferring intracellular macromolecule residues to lysosomes, where they are broken down into biologically active monomers, such as amino acids; this stuation provide cellular metabolic turnover and homeostasis.
Research assistant professor Carol Mercer said, "Cells adapt to nutrient starvation by increasing autophagy
, where a cell basically eats itself and recycles cellular contents to support essential processes until nutrients become plentiful once again.
Several of the genes homologous to LRBA are involved in autophagy
. WDFY3 (WD and FYVE zinc finger domain containing protein 3) encodes a protein that colocalizes with autophagosome markers (36,37).
Hypoxia affected cell viability, apoptosis, and autophagy
was determined by Beclin-1 and LC3B immunocytochemistry staining.