autophagosome


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autophagosome

 [aw″to-fa´go-sōm]
a secondary lysosome in which elements of a cell's own cytoplasm are digested.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

au·to·pha·go·ly·so·some

(aw'tō-fā'gō-lī'sō-sōm),
The digestive vacuole of autophagy that results from the fusion of a lysosome with an autophagic vacuole.
Synonym(s): autophagosome
Farlex Partner Medical Dictionary © Farlex 2012

autophagosome

A membrane-bound intracellular vacuole that contains fragments of partially digested cell components; indigestible debris persists as lipofuscin.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Two ubiquitin-like proteins, ATG8 and ATG12, play an important role in autophagy Conjugation of ATG8 with phosphatidylethanolamine and conjugation of ATG12 with ATG5 are mediated by the El-like protein ATG7, after which these conjugates localize to the developing autophagosome via the E2-like enzymes [19,20].
In the following elongation phase, ATG5 belonging to the ATG12-ATG5-AT-G16L1 conjunction system and LC-3II belonging to the LC3 conjunction system play important roles for autophagosome formation (29).
(2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.
WDFY3 (WD and FYVE zinc finger domain containing protein 3) encodes a protein that colocalizes with autophagosome markers (36,37).
SW480 cells were treated with PPAR[alpha] agonist (clofibrate); the results showed that clofibrate significantly increased autophagosome accumulation (Figure 5(a)).
TEM imaging showed that Exe treatment increased the number of autophagosomes (red arrow) and lipid droplets (yellow arrow) in model mice (Figure 3(a)).
Beclin-1 and LC3B are required for autophagosome formation and maturation, which is one of the most important steps of autophagy.
A higher magnification showed double-membraned autophagosomes containing damaged mitochondria (Figures 3(g), 3(i), and 3(j)).
Intrathecal chloroquine injection into naive mice induces spinal accumulation of LC3 and p62, in parallel with significant mechanical hypersensitivity, thus confirming inhibition of autophagosome clearance and suggesting the participation of autophagy in spinal mechanisms of pain processing.
Autophagosome formation contains four main steps, namely initiation of autophagosomal formation, nucleation of autophagosomal vesicles, elongation of autophagosomal membrane, and recognition of cargos [6].
The involvement of autophagy in the pathogenesis of asthma was demonstrated previously by microscopic examination showing autophagosome formation in fibroblasts from asthmatic patients [26].