autophagosome


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autophagosome

 [aw″to-fa´go-sōm]
a secondary lysosome in which elements of a cell's own cytoplasm are digested.

au·to·pha·go·ly·so·some

(aw'tō-fā'gō-lī'sō-sōm),
The digestive vacuole of autophagy that results from the fusion of a lysosome with an autophagic vacuole.
Synonym(s): autophagosome

autophagosome

/au·to·phago·some/ (-fag´o-sōm) an intracytoplasmic vacuole containing elements of a cell's own cytoplasm; it fuses with a lysosome and the contents are subjected to enzymatic digestion.

autophagosome

A membrane-bound intracellular vacuole that contains fragments of partially digested cell components; indigestible debris persists as lipofuscin.

autophagosome

a secondary lysosome in which elements of a cell's own cytoplasm are digested.
References in periodicals archive ?
The autophagy process is initiated by the engulfing of large sections of a cytoplasm by a crescent-shaped phagophore that elongates into an autophagosome, which subsequently fuses with a lysosome, causing its contents to be degraded by lysosomal hydrolases (Chang et al.
reported that expanded polyglutamine- (polyQ-) induced ER stress activates autophagosome formation with LC3 conversion from LC3-I to -II via the PERK-eIF2[alpha] pathway [44].
cells that cannot form autophagosome, the GAS could survive and proliferate, and was ultimately released from the cells.
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease.
Three well-established methods were adopted to detect autophagosome formation to determine whether diosgenin induces autophagy in CML cells (Mizushima et al.
a)-(b) Analysis of the mitophagy biomarker (BNIP3) and autophagosome regulators (beclin1 and LC3-II) by western blot (a) and densitometry (b).
The mechanisms of this suppression might be that the engulfment of defective mitochondria by autophagosomes limited the release of proapoptotic proteins such as cytochrome c and apoptosis-inducing factors into the cytosol.
p62/SQSTM1 and HDAC6 interact with Ambra1 and Beclin1, prompting the accumulation of the autophagosome to mitochondria [213, 214]; interestingly, studies in p62 knockout mice showed that p62 also mediates mitochondrial perinuclear clustering [212].
The mTOR pathway, a major negative regulator of autophagy, phosphorylates Atg13 and reduces Atg13-ULK1 interaction, thereby inhibiting the formation of a trimeric complex required for autophagosome formation (Yang et al.
TFEB overexpression in cultured cells significantly increases the number of autophagosomes and induces lysosomal biogenesis [9, 10].
Autophagosome accumulation can be detected with a fluorescence microscope.
In the current study, we found that [alpha]-TOS produced early induction of autophagy manifested by increased beclin-1 protein level and an early increase in the expression of LC3B protein, responsible for the completion of the autophagosome formation, which recovered after prolonged incubation to control value.