autonomic failure

autonomic failure

A condition characterised by sympathetic and often parasympathetic failure. AF can be divided into primary, secondary and drug-induced forms, with considerable overlap.
 
Aetiology
AF may be evoked by or associated with ageing, alcohol consumption, carcinomatous autonomic neuropathy, CNS disease, dopamine beta-hydroxylase deficiency, familial dysautonomia (Riley-Day syndrome), idiopathic orthostatic hypotension, Parkinson’s disease, and Shy-Drager syndrome.

Clinical findings
Syncope, orthostatic hypotension.

autonomic failure

Neurology A condition characterized by sympathetic and often parasympathetic failure; Clinical Syncope, orthostatic hypotension; AF can be divided into 1º, 2º, and drug-induced forms with considerable overlap Etiology AF may be evoked by or associated with aging, alcohol imbibition, carcinomatous autonomic neuropathy, CNS disease, dopamine β-hydroxylase deficiency, familial dysautonomia or Riley-Day syndrome, idiopathic orthostatic hypotension, Parkinson's disease, Shy-Drager syndrome. See Baroreflex failure.
References in periodicals archive ?
23) An aerobic exercise regimen of walking or stair climbing 30 to 45 minutes/day 3 days/week for 6 months was shown to eliminate symptoms of orthostasis on tilt table testing in elderly patients with cardiac deconditioning, as opposed to chronic autonomic failure.
Other processes are described in the literature, including pure autonomic failure (PAF) and familial dysautonomia, which may also result in orthostatic hypotension.
Probable MSA also specifies that the patient show either autonomic failure involving urinary incontinence--this includes erectile dysfunction in men--or, if autonomic failure is absent, orthostatic hypotension within 3 minutes of standing by at least 30 mm Hg systolic pressure or 15 mm Hg diastolic pressure.
It is indicated to treat orthostatic dizziness, lightheadedness in adult patients with symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure, dopamine beta-hydroxylase deficiency, and non-diabetic autonomic neuropathy.
NOH is a rare, chronic and often debilitating drop in blood pressure upon standing that is associated with Parkinson's disease, multiple-system atrophy, and pure autonomic failure.
Structural changes in the midbrain causing autonomic failure and 'cell memories' are put forward to explain the aetiology of violence and aggression.
2) The most definitive publication on autonomic failure was published in a comprehensive book in 1983.
There was no evidence that participants had heart problems or autonomic failure (a nervous system disorder) causing fainting, and no twin pair reported a family history of sudden cardiac death.
Approximately 74% of patients exhibit autonomic failure, 87% experience Parkinsonism, 54% experience cerebellar ataxia, and 49% exhibit pyramidal signs such as paralysis, muscle weakness, loss of muscle control, and tremor.
Patterns of neuropathy and autonomic failure in patients with amyloidosis.
Northera (droxidopa), the lead investigational agent in Chelsea Therapeutics' broad pipeline, is currently in Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension (NOH) in patients with primary autonomic failure -- a group of diseases that includes Parkinson's disease, multiple system atrophy (MSA) and pure autonomic failure (PAF).
of the 11 patients, 7 had pure autonomic failure (PAF), 3 Parkinson disease (2 with persistent, consistent orthostatic hypotension), and 1 multiple system atrophy (MSA).

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