autonomic failure

autonomic failure

A condition characterised by sympathetic and often parasympathetic failure. AF can be divided into primary, secondary and drug-induced forms, with considerable overlap.
 
Aetiology
AF may be evoked by or associated with ageing, alcohol consumption, carcinomatous autonomic neuropathy, CNS disease, dopamine beta-hydroxylase deficiency, familial dysautonomia (Riley-Day syndrome), idiopathic orthostatic hypotension, Parkinson’s disease, and Shy-Drager syndrome.

Clinical findings
Syncope, orthostatic hypotension.

autonomic failure

Neurology A condition characterized by sympathetic and often parasympathetic failure; Clinical Syncope, orthostatic hypotension; AF can be divided into 1º, 2º, and drug-induced forms with considerable overlap Etiology AF may be evoked by or associated with aging, alcohol imbibition, carcinomatous autonomic neuropathy, CNS disease, dopamine β-hydroxylase deficiency, familial dysautonomia or Riley-Day syndrome, idiopathic orthostatic hypotension, Parkinson's disease, Shy-Drager syndrome. See Baroreflex failure.
References in periodicals archive ?
Autonomic failure is an integral component of Parkinson's disease (PD), and orthostatic hypotension (OH) can be an important clue to the underlying cardiovascular autonomic failure.
According to a new LSU Pennington Biomedical Research Center USA study, a novel biomarker might give us answers necessary to create a diagnostic tool for hypoglycemia-associated autonomic failure (HAAF).
According to a new LSU Pennington Biomedical Research Center study, a novel biomarker might give us answers necessary to create a diagnostic tool for hypoglycemia-associated autonomic failure (HAAF).
Neurogenic OH (NOH), a commonly overlooked subtype of OH, is associated with nervous system impairment, and is predominantly seen in neurodegenerative disorders such as PD, multiple system atrophy (MSA), and pure autonomic failure (PAF).
A systematic review of autonomic dysfunction in [alpha]-synucleinopathies revealed that cardiovascular autonomic failure has a significant impact on daily activities and QoL.
The Ewing score (ES) ranging from 0 (normal) to 5 (severe autonomic failure) represents the sum of the responses to the different tests.
Practical bedside investigation of diabetic autonomic failure. In: Autonomic failure.
Other important examinations that can be done in order to understand the complex differential diagnosis of this syndrome include total sweating test to recognize areas of anhidrosis, cardiovascular reflex tests to recognize the presence of autonomic failure, microneurography from the peroneal nerve to record muscle sympathetic nerve activity and skin sympathetic nerve activity in the same innervation field, and a skin biopsy.
Bannister, "Autonomic disturbances in spinal cord lesions," in Autonomic Failure: A Textbook of Clinical Disorders of the Autonomic Nervous System, D.
who found length-dependent somatic and autonomic small fiber damage, both in patients with PD and in those with pure autonomic failure (PAF).
Other processes are described in the literature, including pure autonomic failure (PAF) and familial dysautonomia, which may also result in orthostatic hypotension.
Probable MSA also specifies that the patient show either autonomic failure involving urinary incontinence--this includes erectile dysfunction in men--or, if autonomic failure is absent, orthostatic hypotension within 3 minutes of standing by at least 30 mm Hg systolic pressure or 15 mm Hg diastolic pressure.

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