autolysosome


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autolysosome

(ot″ŏ-lī′sŏ-sōm″) [ auto- + lysosome]
Any of the lysosomes that enable digestion of injured portions of the cell in which they are located.

autolysosome

a vacuolar element of the lysosome system of cells to which hydrolases have been added by fusion with lysosomes.

hepatocellular a's
participate in the formation of cytosegresome formations in the liver when damaged hepatocytes are surrounded by an isolating membrane.
References in periodicals archive ?
Moreover, we have fund that EMS horses suffer for reduced mitochondrial biogenesis, limited fusion, and abundance of autophagosomes and autolysosomes formation that affects their "sternness.
Autophagic flux was calculated as the difference between LC3-II levels in the absence (0 hr) and presence (4 hr) of autolysosome inhibitors bafilomycin A1 (0.
These sections revealed structures within the dinoflagellate cells that appeared in TEM preparations to correspond with dinoflagellate autolysosomes (Schmitter, 1971; Schmitter and Jurkiewicz, 1981).
7) Moreover, all stages of autophagosome biogenesis were observed in Atg5-deficient MEFs, including formation of isolation membranes (membrane cisternae curving around a part of the cytoplasm), autophagosomes (double-membrane vacuoles generated by sealing of the edges of the isolation membrane), and autolysosomes (single-membrane vacuoles generated by fusion of an autophagosome and lysosome).
Some lamellated phagolysosomes or autolysosomes were also seen with variably electron-dense material.
Electron microscopy revealed formation of autophagosomes and autolysosomes in HL-60bcl-2 cells after exposure to VK2.
2004a, b) argue from ultrastructural evidence that NPs control their own reduction in size by becoming autophagic through the action of "cell-size-reducing autolysosomes.
LC3 turnover assay is one of the primary methods to evaluate autophagic flux, which is based on the observation that LC3-II is degraded in autolysosomes.
Exocytosis of autolysosomes as a mechanism of TFEB-mediated cellular clearance in Pompe disease," Autophagy, vol.
The substrate (cargo) for autophagy is degraded by lysosomal acid hydrolases, including cathepsins D, B, and L, after the fusion of lysosomes and autophagosomes to form autolysosomes.
As shown in Figures 4(a) and 4(b), compared with the PSB control, 3-MA treatment resulted in a decrease of number of autolysosomes and autophagy vacuoles.