In other solid tumors, the patients may benefit from autologous transplantation
in presence of the following special conditions (24):
Boccadoro M, Cavallo F, Nagler A, Ben Yehuda D, Omede P, Cavalli M, Levi A, Crippa C, Siniscalchi A, Brasca P, Carella AM, Zanetti BA, Patriarca F, Pezzati S, Montefusco V, Stanevsky A, Lupo B, Caravita T, Di Raimondo F, Palumbo AR Melphalan/prednisone/lenalidomide (MPR) versus high-dose melphalan and autologous transplantation
(MEL200) in newly diagnosed multiple myeloma (MM) patients: a phase III trial.
However, this was invalid for autologous transplantations
, because the TRM rate in the auto-HSCT patients was much higher than acceptable thresholds.
Mozobil was approved in the United States in December 2008 where it is indicated for use in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the bloodstream for collection and subsequent autologous transplantation
in patients with non-Hodgkin's lymphoma and multiple myeloma.
Discovering this novel, autologous transplantation
method, where there is no rejection.
Currently, Opexa's main focus is the development of MDSC technology as a platform for the ex vivo generation of MDI for potential application in autologous transplantation
cell therapy for diabetes mellitus patients.
The authors theorize that a delay between the onset of complete remission and the initiation of post-remission treatment might account for the failure of autologous transplantation
to improve survival.
Being that BrainStorm's cell treatment is based on Adult Stem Cells and an autologous transplantation
, our scientists believe that the treatment is safe and do not expect any adverse effects.
The committee endorsed the company's data, suggesting that adding Stemgen to Neupogen in patients undergoing autologous transplantation
increased the proportion of patients able to reach a target number of stem cells to permit transplantation and that the risk/benefit ratio supports the indication.
Product provides enhanced mobilization of stem cells for autologous transplantation
in Non-Hodgkin's Lymphoma and Multiple Myeloma patients
The NTF cells are generated from adult bone marrow derived stem cells, and intended for autologous transplantation
in Parkinson's patients.
BrainStorm's actual approach would involve autologous transplantation