Patients without a donor were randomized to either consolidation/maintenance chemotherapy for 2.5 years or a single autologous transplant
. Prior to treatment, all patients received three courses of high-dose methotrexate as intensification therapy.
What are the odds of the child needing an autologous transplant
, how would one determine these odds, and would there be guarantee of viable cells?
Holding back tears she said: "The autologous transplant
will only prolong Wesley's life a little more than six months.
Patients in the study were given induction chemotherapy followed by autologous transplant
After a median follow-up of 4 years, relapses were most frequent in the cytarabine group (61%) less common in the autologous transplant
group (48%), and lowest in the allogeneic transplant group (29%).
Therefore, the use of autologous transplants
or synthetic materials is required to replace the tissue.
Analysis of factors that influence hematopoitic recovery in autologous transplanted
patients with hematopoietic stem cells from peripheral blood.
use the patient's own blood cells, while allogenic transplants use cells from a matched donor.
For instance, it is generally accepted as a sign of engraftment failure and disease recurrence in autologous transplants
The NCCCR has also processed about 36 autologous transplants
so far for blood related cancer treatment, an official said Wednesday.
The finding provides a scientific basis for enhancing the effectiveness of autologous bone marrow transplants, in which the recipient donates his or her own stem cells prior to the procedure."Up to 10 percent of bone marrow donors fail to mobilize sufficient numbers of stem cells, which impedes autologous transplants
and significantly delays transplant recovery time," said Hartmut Geiger, Ph.D., a researcher in the division of Experimental Hematology/Cancer Biology at Cincinnati Children's and senior investigator on the study.
However, the chemotherapy agents associated with autologous transplants
can have long-lasting cardiopulmonary, immunosuppressive, renal, and other side effects that affect quality of life (Buchsel & Whedon, 1995).