autologous chondrocyte implantation


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autologous chondrocyte implantation

Abbreviation: ACI
The surgical collection of cartilage from a healthy joint, followed by the culturing of its cells and the return of those cells to a damaged or arthritic joint in another part of the body.
Synonym: autologous chondrocyte transplantation
See also: implantation
References in periodicals archive ?
Brewster et al., "Outcomes of Autologous Chondrocyte Implantation in Study of the Treatment of Articular Repair (STAR) PatientsWith Osteochondritis Dissecans," The American Journal of Sports Medicine, vol.
Gillogly SD 2002 Autologous chondrocyte implantation: complex defects and concomitant procedures Operative Techniques in Sports Medicine 10 120-128
Autologous chondrocyte implantation has been shown to be a good option for the management of both medium sized and large chondral defects.
When a patient is considered a candidate for autologous chondrocyte implantation, arthroscopy is performed to assess the diameter and depth of the lesion and any maltracking.
Lee, "Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study," The American Journal of Sports Medicine, vol.
Ludvigsen et al., "Autologous chondrocyte implantation compared with microfracture in the knee: a randomized trial," The Journal of Bone & Joint Surgery, vol.
More recent techniques aim to regenerate the cartilage, such as autologous chondrocyte implantation (ACI) [28, 29], using various cell types--including SCs, chondrocytes, SCs with periosteum, chondrocyte precursors, or a combination of these [4].
Abbreviations AC: Articular cartilage ACI: Autologous chondrocyte implantation ADSCs: Adipose-derived stem cells BMI: Body mass index BMSCs: Bone mesenchymal stem cells CT: Computed tomography CDPCs: Chondrocyte-derived progenitor cells HA: Hyaluronic acid KOOS: Knee injury and osteoarthritis outcome score ICRS: International Cartilage Repair Society MRI: Magnetic resonance imaging OA: Osteoarthritis PBSCs: Peripheral blood stem cells PRP: Platelet-rich plasma RCT: Randomized controlled trial SVF: Stroma vascular fraction.
Triantafillopoulos, "Autologous chondrocyte implantation for knee cartilage injuries: moderate functional outcome and performance in patients with high-impact activities," Orthopedics, vol.
The therapeutic use of MSCs for cartilage repair has been advocated to overcome the limitations of autologous chondrocyte implantation approaches, such as issues related to the dedifferentiation of chondrocytes during expansion culturing and the impact of removal of undamaged cartilage from the same joint.
Cell-based approaches are increasingly gaining attention in the development of treatments for articular cartilage defects [1-4], especially since the clinical application of autologous chondrocytes for articular cartilage repair in 1994 (autologous chondrocyte implantation, ACI) [5, 6].
Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery.

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