autologous bone marrow transplantation


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Related to autologous bone marrow transplantation: Hematopoietic stem cell transplantation

autologous bone marrow transplantation

A procedure in which haematopoietic stem cells are extracted (apheresed) from a patient with lymphoma and other cancers, who is treated with high-dose chemo- and/or radiotherapy to eliminate malignant cells in the bone marrow. The stem cells are then administered. ABMT is a standard second-line therapy for some lymphomas; it has a low risk of infection and has no risk of graft-versus-host disease, which is typical of allogeneic bone marrow transplantation. ABMT is less preferred for patients with acute myeloid leukaemia, in whom the relapse may occur as the patient’s marrow may contain malignant cells.

autologous bone marrow transplantation

Transplantation medicine The administration to an individual 'X' of his/her own BM, often to a leukemic Pt in relapse who, because a suitable HLA-matched donor is not available, would otherwise die of the disease. See Bone marrow.

autologous bone marrow transplantation

Abbreviation: ABMT
The harvesting and preservation of a patient's own blood-forming cells, followed by their eventual reintroduction into a patient. The procedure may be used to treat a variety of cancers and blood disorders. Current practice is to mobilize stem cells into the blood stream with growth factors and then to collect and filter the blood by leukapheresis. In leukapheresis stem cells are identified by a cell surface antigen called CD34. After desirable blood-forming cells with this antigen are removed from the patient's blood, high-dose chemotherapy, monoclonal antibody therapy, or radiation may be used to purge the marrow of diseased cells. Healthy CD34+ cells capable of rebuilding the bone marrow are then returned to the patient and stimulated to reproduce. Synonym: autologous hematopoietic stem cell transplantation
See also: transplantation
References in periodicals archive ?
Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood.
Allogeneic or autologous bone marrow transplantation for acute lymphoblastic leukemia in first complete remission.
Consolidation treatment of adult acute lymphoblastic leukemia: a prospective, randomized trial comparing allogeneic versus autologous bone marrow transplantation and testing the impact of recombinant interleukin-2 after autologous bone marrow transplantation.
Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin's lymphomas who are still responsive to conventional-dose therapy.
Successful immunization of autologous bone marrow transplantation recipients against hepatitis B virus by active vaccination.
Iron overload and liver dysfunction after allogeneic and autologous bone marrow transplantation. Bone Marrow Transplant 1996; 17: 63-6.
A total of 113 patients had suitable donors for allogeneic bone marrow transplantation; the others were randomly assigned to either autologous bone marrow transplantation or to a single course of high-dose cytarabine.
The inaugural DATTA Forum meeting convened representatives of more than 80 major payers, HMOs, and medical centers to discuss the issue of autologous bone marrow transplantation for breast cancer.
Action: Plaintiff sought a declatory judgment that her group health plan, administered by defendant Blue Cross-Blue Shield of Virginia, must cover high-dose chemotherapy with autologous bone marrow transplantation (HDCT-ABMT) for treatment of her stage IV metastatic breast cancer...thus, the Court concludes, on this record, that HDCT-ABMT is not experimental treatment excluded from Blue Cross' plan."
This year, the DATTA program is reevaluating autologous bone marrow transplantation, percutaneous diskectomy, and transrectal ultrasound of the prostate.

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