autoimmune sensorineural hearing loss


Also found in: Acronyms.

autoimmune sensorineural hearing loss

A condition characterised by idiopathic, rapidly progressive, bilateral sensorineural hearing loss, which improves with corticosteroids and immunosuppressants. It is more common in women age 20 to 50.

Clinical findings
Bilateral sensorineural hearing loss which develops over weeks to months, with fluctuating symptoms, reduction in speech discrimination scores; vestibular symptoms occur in half of patients, and include disequilibrium, ataxia, motion intolerance, positional vertigo, and episodic vertigo; up to half of patients complain of tinnitus and aural fullness, and up to one-third have systemic autoimmune disease—e.g., rheumatoid arthritis, ulcerative colitis, systemic lupus erythematosus and polyarteritis nodosa.
References in periodicals archive ?
Increased frequencies of cochlin-specific T cells in patients with autoimmune sensorineural hearing loss. J Immunol 2006; 177: 4203-10.
Paparella, "Autoimmune Sensorineural Hearing Loss: A Human Temporal Bone Study," American Journal of Otolaryngology 19 (1998): 33-39.
Of these 30 patients, 15 (50%) were diagnosed with autoimmune sensorineural hearing loss (ASNHL).
(2.) McCabe BE Autoimmune sensorineural hearing loss. 1979.
(1-3) On the other hand, Parnes et al have been using high-dose dexamethasone--up to 30 and 40 mg/ ml--in humans for the treatment of Cogan's syndrome and sudden autoimmune sensorineural hearing loss, and their results suggest that steroids are not toxic.
Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease.
The goal of this study was to assess the effects of immunosuppressive therapy on hearing in patients with presumed autoimmune sensorineural hearing loss (AISNHL) and a Western blot assay positive for a 68 kD inner ear antigen.

Full browser ?