autoimmune pancreatitis


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autoimmune pancreatitis

A condition characterised by diffuse enlargement of the pancreas and irregular stenosis of the main pancreatic duct (less commonly, also of the intrapancreatic bile duct on ERCP, associated with other autoimmune diseases).

Lab
Increased IgG4 autoantibodies.

Management
Corticosteroids.

autoimmune pancreatitis

Chronic pancreatitis, usually found in association with other autoimmune disorders (e.g., inflammatory bowel disease, rheumatoid arthritis, or Sjogren's syndrome). It is a relatively rare disease, suggested by the finding of antibodies against lactoferrin and carbonic anhydrase in the blood of affected patients. Biopsy specimens reveal infiltration of the organ by lymphocytes. It is treated with corticosteroids.
Synonym: autoimmune-related pancreatitis
See also: pancreatitis

autoimmune pancreatitis

Inflammation of the pancreas featuring an autoimmune process with obvious lymphocyte infiltration and fibrosis causing organ dysfunction. The disease takes a range of forms and includes conditions formerly known as chronic sclerosing pancreatitis, non-alcoholic duct-destructive chrinic pancreatitis, pseudotumerous pancreatitis and duct-narrowing chronic pancreatitis.
References in periodicals archive ?
Differences in clinical profile and relapse rate of type 1 versus type 2 autoimmune pancreatitis. Gastroenterol 2010;139:140-8.
Chronic gastritis in the setting of autoimmune pancreatitis. Am J Surg Pathol 2010 Sep;34(9):1241-1249.
Tzilves, "Challenge in the pathogenesis of autoimmune pancreatitis: potential role of Helicobacter pylori infection via molecular mimicry," Gastroenterology, vol.
Chari, "Possible association between IgG4associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma," Pancreas, vol.
De Muckadell, "Laparoscopic and percutaneous core needle biopsy plays a central role for the diagnosis of autoimmune pancreatitis in a single-center study from Denmark," Pancreas, vol.
Circulating Treg-type [CD4.sup.+] T cells are increased in the peripheral blood of patients with IgG4-related autoimmune pancreatitis. (18) Treg cells (as defined by immunohistochemical expression of the Treg-related transcription factor Foxp3) are also increased in liver biopsies from patients with IgG4-RD.
Takazakura, "IgG4-associated idiopathic tubulointerstitial nephritis complicating autoimmune pancreatitis," Nephrology Dialysis Transplantation, vol.
IgG4-associated cholecystitis: another clue in the diagnosis of autoimmune pancreatitis. Dig Dis Sci.
Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease.
Autoimmune pancreatitis: (also termed lymphoplasmacytic sclerosing, chronic sclerosing and non-alcoholic duct destructive chronic pancreatitis) deserves special mention.

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