autoimmune liver disease

autoimmune liver disease

A family of chronic, slowly progressive, inflammatory liver diseases with overlapping features.

Entities
Autoimmune hepatitis (a parenchymal disease); primary biliary cirrhosis and sclerosing cholangitis (both biliary diseases).
References in periodicals archive ?
More recent studies have suggested that antibiotics may also increase the risk of autoimmune conditions such as type 1 diabetes, autoimmune liver disease, and juvenile idiopathic arthritis.
They suggest antibiotics could also increase the risk of autoimmune conditions such as type 1 diabetes, autoimmune liver disease and juvenile idiopathic arthritis.
CymaBay's lead development candidate, seladelpar, is a potent, selective and orally active PPAR agonist currently in development for the treatment of patients with primary biliary cholangitis (PBC), an autoimmune liver disease, and with nonalcoholic steatohepatitis (NASH).
Review article: overlap syndromes and autoimmune liver disease. Aliment Pharmacol Ther.
Dr Gideon Hirschfield, senior lecturer and consultant hepatologist with the University Hospitals Birmingham, UK, and a specialist in the field of gastroenterology, including autoimmune liver disease, will visit from February 17 to 21.
As noted, autoimmune antibody production has been associated with EBV, (14) and the presence of positive autoimmune antibodies and elevated serum transaminase levels will often raise the possibility of autoimmune liver disease. The presence of positive EBV serologies, elevated levels of IgG, and the presence of other autoantibodies (anti-smooth muscle cell antibodies or liver-kidney-microsomal antibodies) can help distinguish EBV hepatitis from autoimmune hepatitis.
To date, the current case represents the first reported case of an overlap involving systemic lupus erythematosus, autoimmune hepatitis, and inflammatory myopathy Autoimmune liver disease may be associated with extrahepatic inflammatory manifestations (3).
The findings, published in Science, suggest promising new approaches for treating chronic autoimmune conditions, including systemic lupus and autoimmune liver disease, the researchers said.
Studies have demonstrated that changes in the gut microbiota play important roles in inducing and promoting the development of liver diseases, and the diversity of the gut microbiota has been associated with alcoholic liver disease, autoimmune liver disease, chronic hepatitis B (CHB), cirrhosis and HCC; moreover, changes in the intestinal flora are dependent on the various pathogeneses that are present [4-8].
They showed that the top four etiologies of cirrhosis were HBV, HCV, ALD, and autoimmune liver disease. The prevalence of HBV cirrhosis has decreased in the recent 12 years, which is related with the increased coverage of HBV vaccination in China.
Autoimmune liver disease (AILD) comprises a group of immune-mediated liver diseases that include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC) [1].
Exclusion criteria were: any treatments that could affect bone mass (calcium, bisphosphonates, estrogens, vitamin D supplements, corticosteroids, and active intravenous drugs.), history of hip or lumbar spine fracture, history of malignancy, severe heart disease, chronic kidney disease, human immunodeficiency virus (HIV) coinfection, malnutrition, and other chronic liver disease, such as chronic hepatitis C, primary biliary cirrhosis, alcoholic liver disease, autoimmune liver disease, bone disorders.

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