autoimmune sensorineural hearing loss

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autoimmune sensorineural hearing loss

A condition characterised by idiopathic, rapidly progressive, bilateral sensorineural hearing loss, which improves with corticosteroids and immunosuppressants. It is more common in women age 20 to 50.

Clinical findings
Bilateral sensorineural hearing loss which develops over weeks to months, with fluctuating symptoms, reduction in speech discrimination scores; vestibular symptoms occur in half of patients, and include disequilibrium, ataxia, motion intolerance, positional vertigo, and episodic vertigo; up to half of patients complain of tinnitus and aural fullness, and up to one-third have systemic autoimmune disease—e.g., rheumatoid arthritis, ulcerative colitis, systemic lupus erythematosus and polyarteritis nodosa.
References in periodicals archive ?
Currently, it is believed that testing the presence of the Hsp70 protein and the level of anti-Hsp70 auto-antigen may be helpful in the serological diagnosis of autoimmune hearing loss. It is believed that these proteins are the only available diagnostic markers that identify the origin of autoimmune hearing loss [3, 30].
After the introduction of the concept of autoimmune hearing loss by McCabe (1, 2) in 1979 (3, 4), corticosteroids began to be used systemically for the treatment of many inner ear diseases.
However, in the pathogenesis of autoimmune hearing loss, the immune system itself damages the inner ear.
subsequently completed the definition of McCabe and introduced the distinction between primary or secondary autoimmune hearing loss, i.e., associated with a systemic autoimmune disease [12].
There are some reports indicating that anti-tumor necrosis factor alpha agents (etanercept, adalimumab and infliximab) may offer additional treatment options for patients with autoimmune hearing loss. (20-22)
The patient was treated with a 2-week course of high-dose systemic steroids, a course of intratympanic steroids, a diuretic, and dietary salt restriction for suspected autoimmune hearing loss, as well as possible Meniere disease.
When McCabe described autoimmune hearing loss, initially, he defined it on the basis of laboratory findings and clinical characteristics, such as its responsiveness to steroid therapy.
Infections: bacterial, viral, fungal Autoimmune hearing loss
Facer et al., "Use of methotrexate for autoimmune hearing loss," Annals of Otology, Rhinology, & Laryngology, vol.
Another 2 patients (1.7%) had an autoimmune hearing loss, and both were treated with a corticosteroid.
Autoantibodies to recombinant human CTL2 in autoimmune hearing loss. Laryngoscope 2009; 119(5):924-32.
Glucocorticoids have been used to treat disorders such as sudden sensorineural hearing loss, autoimmune hearing loss, Meniere's disease, and hearing loss secondary to trauma, viral insult, and idiopathic causes.

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