autoimmune sensorineural hearing loss

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autoimmune sensorineural hearing loss

A condition characterised by idiopathic, rapidly progressive, bilateral sensorineural hearing loss, which improves with corticosteroids and immunosuppressants. It is more common in women age 20 to 50.

Clinical findings
Bilateral sensorineural hearing loss which develops over weeks to months, with fluctuating symptoms, reduction in speech discrimination scores; vestibular symptoms occur in half of patients, and include disequilibrium, ataxia, motion intolerance, positional vertigo, and episodic vertigo; up to half of patients complain of tinnitus and aural fullness, and up to one-third have systemic autoimmune disease—e.g., rheumatoid arthritis, ulcerative colitis, systemic lupus erythematosus and polyarteritis nodosa.
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References in periodicals archive ?
Currently, it is believed that testing the presence of the Hsp70 protein and the level of anti-Hsp70 auto-antigen may be helpful in the serological diagnosis of autoimmune hearing loss. It is believed that these proteins are the only available diagnostic markers that identify the origin of autoimmune hearing loss [3, 30].
Circulating Immune Complexes and Heat Shock Protein 70 in the Sera of Patients with Sudden Sensorineural Hearing Loss
After the introduction of the concept of autoimmune hearing loss by McCabe (1, 2) in 1979 (3, 4), corticosteroids began to be used systemically for the treatment of many inner ear diseases.
Are There Any Systemic Effects of the Intratympanic Administration of Dexamethasone?/Intratimpanik Deksametazonun Sistemik Etkisi Var mi?
However, in the pathogenesis of autoimmune hearing loss, the immune system itself damages the inner ear.
The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss
subsequently completed the definition of McCabe and introduced the distinction between primary or secondary autoimmune hearing loss, i.e., associated with a systemic autoimmune disease [12].
Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment
There are some reports indicating that anti-tumor necrosis factor alpha agents (etanercept, adalimumab and infliximab) may offer additional treatment options for patients with autoimmune hearing loss. (20-22)
Sensorineural hearing impairment and subclinical atherosclerosis in rheumatoid arthritis patients without traditional cardiovascular risk factors
The patient was treated with a 2-week course of high-dose systemic steroids, a course of intratympanic steroids, a diuretic, and dietary salt restriction for suspected autoimmune hearing loss, as well as possible Meniere disease.
Sympathetic hearing loss: a review of current understanding and report of 2 cases
When McCabe described autoimmune hearing loss, initially, he defined it on the basis of laboratory findings and clinical characteristics, such as its responsiveness to steroid therapy.
Autoimmune sensorineural hearing loss
Infections: bacterial, viral, fungal Autoimmune hearing loss
Tinnitus: questions to reveal the cause, answers to provide relief
Facer et al., "Use of methotrexate for autoimmune hearing loss," Annals of Otology, Rhinology, & Laryngology, vol.
Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan's Syndrome
Another 2 patients (1.7%) had an autoimmune hearing loss, and both were treated with a corticosteroid.
Vertigo in elderly patients: a review of 164 cases in Brazil
Autoantibodies to recombinant human CTL2 in autoimmune hearing loss. Laryngoscope 2009; 119(5):924-32.
Treatment-refractory autoimmune sensorineural hearing loss: response to infliximab
Glucocorticoids have been used to treat disorders such as sudden sensorineural hearing loss, autoimmune hearing loss, Meniere's disease, and hearing loss secondary to trauma, viral insult, and idiopathic causes.
Potential complications associated with steroid use in the middle and inner ear

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