autoimmune haemolytic anaemia


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autoimmune haemolytic anaemia

A condition in which IgG autoantibodies are directed against a component of Rh factor coat red cell surfaces.
 
Aetiology
Idiopathic (±50%), SLE, CLL, lymphomas.
 
Clinical finding
Anaemia of rapid onset, fatigue with angina or CHF, jaundice, splenomegaly.
 
Lab
Anaemia, spherocytosis, nucleated RBCs, positive direct Coombs test.
 
Management
Prednisone, IV immune globulin, splenomegaly.
 
Prognosis
Good.
References in periodicals archive ?
Evans syndrome is a rare disease that is associated with Coombs positive autoimmune haemolytic anaemia and autoimmune thrombocytopenia.
[8] In our study, 2 children were diagnosed as having Autoimmune haemolytic anaemia (3.84%).
The children were diagnosed as having the following types of haemolytic anaemia: Thalassemia major constituted 12 cases (36.36%); Thalassemia trait, 1 case (3%); Sickle cell anaemia, 11 cases (3.33%); Sickle cell trait, 4 cases (12.12%); Sickle thalassemia, 4 cases (12.12%); Hereditary persistence of foetal haemoglobin, 1 case (3%); Malaria, 17 cases (32.69%); and Autoimmune haemolytic anaemia, 2 cases (3.84%).
Patients with a falling Hb on AZT (or AZT-containing regimen) should be investigated for other causes of anaemia, usually nutritional or infective, but autoimmune haemolytic anaemia should also be considered.
Red blood cell transfusion in warm-type autoimmune haemolytic anaemia. Lancet 1992;340:1515-7.
Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases.
These are IgG- and IgM-mediated disorders that produce positive direct antiglobulin (Coombs') tests that are clinically and serologically indistinct from autoimmune haemolytic anaemia. Drug-induced immune haemolysis may occur by one of three mechanisms.
An association between thalassemia and autoimmune haemolytic anaemia (AIHA).
Autoimmune haemolytic anaemia is characterised by the formation of auto-antibodies that bind to the erythrocyte surface membrane, leading to haemolysis.
Life saving cyclophosphamide treatment in a girl with giant cell hepatitis and autoimmune haemolytic anaemia: case report and up-to-date on therapeutical options.
Autoimmune Haemolytic Anaemia (AIHA), an acquired extra corpuscular blood disorder, is one of the earliest described immune disorders with an annual incidence of 1 per 80,000 cases to 2.6 per 100,000.

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