autoimmune gastritis

(redirected from autoimmune atrophic gastritis)

autoimmune gastritis

A rare form of chronic atrophic gastritis, which is most common in African Americans and northern Europeans, characterised by autoimmune destruction of fundic and body glands.

Lab
Serum antiparietal and anti-intrinsic factor antibodies that cause IF deficiency, decreasing available cobalamin, often linked to megaloblastic anaemia
References in periodicals archive ?
Type 1 is a small, multifocal, polypoid tumor with a predilection for the gastric body and strong association with chronic autoimmune atrophic gastritis. On the other hand, type 2 G-NET, which is also multifocal, develops in association with multiple endocrine neoplasms type 1 (MEN-1), while type 3 is a sporadic tumor.
D'Amore et al., "Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use," PLoS Pathogens, vol.
A laboratory score in the diagnosis of autoimmune atrophic gastritis: a prospective study.
Correlate pernicious anemia with autoimmune atrophic gastritis.
Which of the following conditions does not have symptoms related to those observed in autoimmune atrophic gastritis?
RELATED ARTICLE: Autoimmune atrophic gastritis leads the way to pernicious anemia
Recent evidence suggests that H pylori can trigger the development of autoimmune atrophic gastritis through a process of molecular mimicry in which the bacterial organisms take on the antigenic appearance of parietal cells.
In autoimmune atrophic gastritis, autoant-bodies cause destruction of the parietal cell mass that makes up the gastric mucosa.
Autoimmune atrophic gastritis typically causes symptoms related to vitamin B12 (cobalmin) deficiency, including anemia, gastrointestinal symptoms, and neurologic symptoms, including dementia.
Patients with autoimmune atrophic gastritis have high levels of antiparietal and anti-intrinsic factor antibodies (types 1 and 2 antibodies to intrinsic factor).
The loss of intrinsic factor caused by autoimmune atrophic gastritis ("pernicious anemia") is one of the most frequent causes of severe vitamin B12 deficiency [5, 6].
High levels of B12 could also be explained, to some extent, by either one of innate errors (hereditary enzymatic disorders), autoimmune atrophic gastritis, neoplastic disorders of the digestive tract or some myelodysplastic syndromes.