autocrine loop

A type of interaction between growth factors, cytokines and target cells, in which a cell produces the same growth factors and cytokines for which it has receptors, allowing the cell to stimulate itself, as occurs in smooth muscle cell production and IL-1 response.

References in periodicals archive ?

sup][26] Interestingly, mast cells are known to release and respond to TNF-a, indicating a positive autocrine loop that leads to the augmentation of mast cell activation.

NF-kappa B and TNF-alpha: A positive autocrine loop in human lung mast cells?

Phloroglucinol Protects the Urinary Bladder Via Inhibition of Oxidative Stress and Inflammation in a Rat Model of Cyclophosphamide-induced Interstitial Cystitis

It has been shown that VEGF-A induces proliferation, survival, and protection of AML cells against apoptosis by an autocrine loop via VEGFR signaling (31), (32), (33).

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.

Gene expression of VEGF-A and VEGF-C in peripheral blood mononuclear cells of Iranian patients with acute myeloid leukemia / Akut Miyeloid Losemili iranli Hastalarin Periferik Kan Mononukleer Hucrelerinde VEGF-A ve VEGF-C Gen Ekspresyonu

Blockade of the insulin-like growth factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop.

Biological & physiological aspects of action of insulin-like growth factor peptide family

It increases production of vascular endothelial growth factor (VEGF), the main angiogenic factor, which in turn enhances the expression of CXCR4 receptor in endothelial cells, in an autocrine loop (3).

SDF1-3'A gene polymorphism is associated with chronic myeloproliferative disease and thrombotic events

46] The exuberant endothelial proliferation involves an autocrine loop of endothelial secretion of basic fibroblast growth factor.

Intravascular papillary endothelial hyperplasia (Masson's tumor) manifesting as a lateral neck mass

An autocrine loop signaling pathway involving VEGF and VEGFR2 has recently been reported in leukemias.

ImClone Systems Presents Preclinical Findings on Anti-VEGF Receptor Therapy in Human Leukemia Model

The differential sensitivity of prostate cancer cells to TGF-[alpha] suggests that the autocrine loop involving TGF-[alpha] in prostate cancer cell lines may be further regulated by other unknown factors.

In human prostatic carcinomas, in situ hybridization studies have shown increased expression of the KGF gene and receptor in epithelial cells of high-grade carcinomas but not in benign hyperplasia of the prostate, suggesting a switch from a paracrine to an autocrine loop (55, 56).

Growth factor involvement in progression of prostate cancer

Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop.