autocrine loop

autocrine loop

A type of interaction between growth factors, cytokines and target cells, in which a cell produces the same growth factors and cytokines for which it has receptors, allowing the cell to stimulate itself, as occurs in smooth muscle cell production and IL-1 response.
References in periodicals archive ?
sup][26] Interestingly, mast cells are known to release and respond to TNF-a, indicating a positive autocrine loop that leads to the augmentation of mast cell activation.
NF-kappa B and TNF-alpha: A positive autocrine loop in human lung mast cells?
It has been shown that VEGF-A induces proliferation, survival, and protection of AML cells against apoptosis by an autocrine loop via VEGFR signaling (31), (32), (33).
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.
Blockade of the insulin-like growth factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop.
It increases production of vascular endothelial growth factor (VEGF), the main angiogenic factor, which in turn enhances the expression of CXCR4 receptor in endothelial cells, in an autocrine loop (3).
46] The exuberant endothelial proliferation involves an autocrine loop of endothelial secretion of basic fibroblast growth factor.
An autocrine loop signaling pathway involving VEGF and VEGFR2 has recently been reported in leukemias.
The differential sensitivity of prostate cancer cells to TGF-[alpha] suggests that the autocrine loop involving TGF-[alpha] in prostate cancer cell lines may be further regulated by other unknown factors.
In human prostatic carcinomas, in situ hybridization studies have shown increased expression of the KGF gene and receptor in epithelial cells of high-grade carcinomas but not in benign hyperplasia of the prostate, suggesting a switch from a paracrine to an autocrine loop (55, 56).
Constitutive endothelin-1 overexpression promotes smooth muscle cell proliferation via an external autocrine loop.