autocrine


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Related to autocrine: endocrine, Autocrine signaling

autocrine

 [aw´to-krin]
denoting a mode of hormone action in which a hormone binds to receptors on and affects the function of the same cell that produced it.

au·to·crine

(aw'tō-krin),
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

(ô′tō-krĭn′)
adj.
Relating to the release of chemical substances from endocrine cells that bind to receptors on the same cell that produces them.

autocrine

adjective Referring to a substance (e.g., a growth factor) produced by a cell which stimulates its own secretion.

au·to·crine

(aw'tō-krin)
Denoting self-stimulation through cellular production of a factor and a specific receptor for it.
[auto- + G. krinō, to separate]

autocrine

1. Of a substance secreted by a cell and released into the extracellular fluid, that then acts on the cell.
2. Of a cell responding to such chemical messengers.
References in periodicals archive ?
Tumour co-expression of apelin and its receptor is the basis of an autocrine loop involved in the growth of colon adenocarcinomas.
These data suggest that LIF and LIFR act on endometrial epithelial cells in an autocrine manner and on stromal cells in a paracrine manner.
Autocrine role of macrophage inflammatory protein-1 beta in human T-cell lymphotropic virus type-1 tax-transfected Jurkat T-cells.
The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects.
This peptide acts not only in endocrine but also autocrine and paracrine ways (as a growth factor, neurotransmitter, or immunomodulator) [1].
Signalling molecules, both from autocrine and paracrine sources, can be derived from hormones, ATP, and even neurotransmitters.
It should be kept in mind, however, that adipokines are part of large neuroendocrine-immune-metabolic networks, and they exert their effects through complex endocrine, paracrine, autocrine, or juxtacrine crosstalk mechanisms, which should be further investigated with system medicine approaches.
It has been reported that induction of autocrine production of IL-6 is responsible for interferon alpha-induced growth in MM cells (21).
As IL-21 can be produced by Th17 cells and stimulate the differentiation of Th17 cells to produce IL-17 in an autocrine manner,[sup][17],[18] it can also affect the differentiation, proliferation, and function of CD4+ and CD8+ T-cells and B-cells, which are the main inflammatory cells in patients with DM and PM.[sup][8],[12] We inferred that IL-21 may play a role similar to that of IL-17 in myositis patients.
UVA induced autocrine stimulation of fibroblast-derived collagenase/MMP by interrelated loops of interleeutin-1 and interleukin-6.
Over the last decade, however, numerous studies have demonstrated that WAT is a dynamically active endocrine organ that can produce and secrete biologically active peptides and proteins called adipokines, which have autocrine, paracrine, and endocrine actions.