autoantigen


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autoantigen

 [aw″to-an´tĭ-jen]
an antigen that, despite being a normal tissue constituent, is the target of a humoral or cell-mediated immune response, such as in autoimmune disease.

au·to·an·ti·gen

(aw'to-an'ti-jen),
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

(ô′tō-ăn′tĭ-jən)
n.
An endogenous antigen that stimulates autoantibody production, as in an autoimmune reaction.

autoantigen

Any of an organism’s own antigens (self-antigens)—e.g., glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies.

autoantigen

Immunology Any self antigen–eg, glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies. See Antigen.

au·to·an·ti·gen

(aw'to-an'ti-jĕn)
A "self" antigen; any tissue constituent that evokes an immune response by the host.
References in periodicals archive ?
Boitard, "T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives," Clinical and Developmental Immunology, vol.
Takio et al., "Identification of [alpha]-fodrin as a candidate autoantigen in primary Sjogren's syndrome," Science, vol.
Kwon et al., "[beta]-Tubulin as an autoantigen for autoimmune inner ear disease," International Congress Series, vol.
Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2.
Nakayasu et al., "Using immunoproteomics to identify alpha-enolase as an autoantigen in liver fibrosis," Journal of Proteome Research, vol.
Riera, "Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis," Clinical and Experimental Immunology, vol.
As the major autoantigen of antiphospholipid syndrome (APS), [[beta].sub.2]GPI is closely associated with thrombotic events in patients with APS [2].
In addition, it also functions as an autoantigen in two autoimmune diseases: psoriasis, a chronic inflammatory skin disease [11] and lupus erythematosus, a systemic autoimmune disease [16].
Auto immunity is triggered by CPR -3 (105-201), a protein complimentary to human autoantigen protinease-3.
All chapters have been revised and updated to include recent developments, such as the discovery of the major autoantigen in membranous nephropathy and the latest data on issues in therapeutics like blood pressure targets and the use of RAS (renin-angiotensin system) blockade.
It was demonstrated that antigenic myositis-specific autoantigens are expressed in both tumor cells and myoblasts, and then myositis-specific autoantigen is expressed in an initial tumor leading to the generation of both specific T and B cells targeting those antigens, and subsequently stimulate immune responses previously generated in the anti-tumor response.