autoantigen


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autoantigen

 [aw″to-an´tĭ-jen]
an antigen that, despite being a normal tissue constituent, is the target of a humoral or cell-mediated immune response, such as in autoimmune disease.

au·to·an·ti·gen

(aw'to-an'ti-jen),
A "self" antigen; any tissue constituent that evokes an immune response by the host.

autoantigen

(ô′tō-ăn′tĭ-jən)
n.
An endogenous antigen that stimulates autoantibody production, as in an autoimmune reaction.

autoantigen

Any of an organism’s own antigens (self-antigens)—e.g., glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies.

autoantigen

Immunology Any self antigen–eg, glomerular basement membrane, mitochondria, muscle, parietal cells, thyroglobulin and others, which may evoke production of autoantibodies. See Antigen.

au·to·an·ti·gen

(aw'to-an'ti-jĕn)
A "self" antigen; any tissue constituent that evokes an immune response by the host.
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References in periodicals archive ?
Boitard, "T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives," Clinical and Developmental Immunology, vol.
The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70kDa Heat Shock Protein DnaK in Macrophage Stimulation
Takio et al., "Identification of [alpha]-fodrin as a candidate autoantigen in primary Sjogren's syndrome," Science, vol.
Immune Privilege and Eye-Derived T-Regulatory Cells
Kwon et al., "[beta]-Tubulin as an autoantigen for autoimmune inner ear disease," International Congress Series, vol.
The Role of Autoimmunity in the Pathogenesis of Sudden Sensorineural Hearing Loss
Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2.
Is the Diagnosis of Celiac Disease Possible Without Intestinal Biopsy?
Nakayasu et al., "Using immunoproteomics to identify alpha-enolase as an autoantigen in liver fibrosis," Journal of Proteome Research, vol.
Proteomics-Based Identification of the Molecular Signatures of Liver Tissues from Aged Rats following Eight Weeks of Medium-Intensity Exercise
Riera, "Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis," Clinical and Experimental Immunology, vol.
Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model
As the major autoantigen of antiphospholipid syndrome (APS), [[beta].sub.2]GPI is closely associated with thrombotic events in patients with APS [2].
Redox status of [[beta].sub.2]GPI in different stages of diabetic angiopathy
In addition, it also functions as an autoantigen in two autoimmune diseases: psoriasis, a chronic inflammatory skin disease [11] and lupus erythematosus, a systemic autoimmune disease [16].
Tumor suppressor maspin as a modulator of host immune response to cancer
The synaptic vesicle associated protein amphiphysin is the 128-kD autoantigen of Stiff-Man syndrome with breast cancer.
A stiff person case admitted phsysical medicine and rehabilitation outpatient clinic with low back pain/Bel agrisi sikayetiyle fiziksel tip ve rehabilitasyon poliklinigine basvuran bir stiff person sendromu olgusu
Auto immunity is triggered by CPR -3 (105-201), a protein complimentary to human autoantigen protinease-3.
Granulomatosis with polyangiitis: a case report
All chapters have been revised and updated to include recent developments, such as the discovery of the major autoantigen in membranous nephropathy and the latest data on issues in therapeutics like blood pressure targets and the use of RAS (renin-angiotensin system) blockade.
Comprehensive Clinical Nephrology, 5th Edition (online access included)
It was demonstrated that antigenic myositis-specific autoantigens are expressed in both tumor cells and myoblasts, and then myositis-specific autoantigen is expressed in an initial tumor leading to the generation of both specific T and B cells targeting those antigens, and subsequently stimulate immune responses previously generated in the anti-tumor response.
Metachronous basal cell carcinoma and primary plasmacytic leukemia associated with dermatomyositis

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