aurora kinase


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aurora kinase

an enzyme that plays a role as an essential regulator of cell division. Aurora A and Aurora B kinases are implicated in regulation of spindle assembly and correction of chromosomal segregation.

Aurora kinase

Any of a family of three highly homologous serine/threonine kinases (Aurora kinase A, Aurora kinase B and Aurora kinase C), which play a critical role in regulating many processes that are pivotal to mitosis. Each has a different function in the control of mitosis. They are strongly linked to cancer progression, and while overexpression of Aurora A and B occurs in many cancers, neither is regarded as an oncoprotein (as oncogenic mutations are required to promote tumour progression).
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In December the youngster started Aurora Kinase treatment, just days after he drove down the aisle at his parents' wedding in his favourite remote controlled car.
Last week he started Aurora kinase treatment at Birmingham Children's Hospital.
Scientists claim that the new drug, double-hits the AML cells and works by blocking the FLT3 gene and Aurora kinase protein.
It is the first time young people aged six months to 18 with acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) have received a pioneering class of drugs called aurora kinase inhibitors.
Among the topics are characterizing small-molecule kinase inhibitors in vivo, using analogue sensitive kinases and more specific kinase inhibitors as tools, kinase inhibitors in signal transduction therapy, aurora kinase inhibitors as novel treatments for cancer, cellular protein kinases as antiviral targets, and prospects for tuberculosis therapeutics targeting Mycobacterium tubercolosis phosphosignaling networks.
Unlike other aurora kinase inhibitors currently being studied, MLN8237 selectively targets aurora A Kinase and can be administered orally, Dr Matulonis said.
Researchers with US and European drug companies share insights into growth factor inhibitors VEDFR2, ERBB2, and other kinases; MEK inhibitors; the cell cycle kinase inhibitors Aurora kinase and PLK inhibitors; and related topics.
Aurora Kinase is believed to function in signaling from unattached kinetochores to block progression to anaphase.
A lecture focusing on Aurora kinase inhibitors will be presented today by Dr.
focuses specifically on an aurora kinase inhibitor drug candidate, VX-680,
The report provides a competitor evaluation in the field of synthetic molecules targeting polo-like kinase 1 (Plk-1), cyclin-dependent kinase (CDK) or aurora kinase for treatment of cancer as of September 2011.
It is the first time young people aged six months to 18 with acute lymphoblastic leukaemia and acute myeloid leukaemia have received a pioneering class of drugs called aurora kinase inhibitors.

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