Drugs and agents from several categories, such as Fms-like tyrosine kinase 3 (FLT3) inhibitors, Aurora kinase
(AURK) inhibitors, and immunotherapy have been or are currently being studied in prospective clinical trials.
It is known that Aurora kinase
A and JAK2 pathway activation contributes to GVHD.
Live-cell imaging of a Forster resonance energy transfer (FRET)-based aurora kinase
phosphorylation sensor revealed that midzone substrates were less phosphorylated in AAK-inhibited cells, despite the fact that midzone levels of active phosphorylated ABK (pABK) were normal.
The phosphorylation, or the addition of a phosphate group to a molecule, is carried out by an enzyme called Aurora Kinase
, which has been observed to be present in unusually high levels in some cancers.
In December, Charlie was put forward for Aurora Kinase
treatment, a trial drug, days after he drove down the aisle at his parents' wedding in his favourite remote-controlled car.
Last week he started Aurora kinase
treatment at Birmingham Children's Hospital.
Scientists claim that the new drug, double-hits the AML cells and works by blocking the FLT3 gene and Aurora kinase
His thesis was titled was "Relationship between Aurora Kinase
C and Cancer".
It is the first time young people aged six months to 18 with acute lymphoblastic leukaemia and acute myeloid leukaemia have received a pioneering class of drugs called aurora kinase
Among the topics are characterizing small-molecule kinase inhibitors in vivo, using analogue sensitive kinases and more specific kinase inhibitors as tools, kinase inhibitors in signal transduction therapy, aurora kinase
inhibitors as novel treatments for cancer, cellular protein kinases as antiviral targets, and prospects for tuberculosis therapeutics targeting Mycobacterium tubercolosis phosphosignaling networks.
CYC116, an Aurora kinase
and VEGFR2 inhibitor, is in a Phase 1 trial in patients with solid tumors.
Unlike other aurora kinase
inhibitors currently being studied, MLN8237 selectively targets aurora A Kinase and can be administered orally, Dr Matulonis said.