Bindu, "Postmastectomy-postirradiation atypical vascular lesion of the skin: report of 2 cases," Case Reports in Pathology, vol.
However, differential diagnosis that should be considered following mastectomy and radiotherapy is atypical vascular lesions that occur in the skin within the radiation field.
Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med.
Clinicopathological and immunohistochemical study of 30 cases of post-radiation atypical vascular lesion of the breast.
(8) Coamplification of the FMS-like tyrosine kinase 4 (FLT4) gene encoding the vascular endothelial growth factor receptor 3 (VEGFR3), in association with MYC amplification, was found by Guo et al (10) in 25% of secondary angiosarcomas but not in other radiation-associated, atypical vascular lesions. Based on those results, they suggest that FLT4 overexpression may represent a required second hit in the progression of secondary angiosarcomas.
In 1994, Fineberg and Rosen3 reported 4 cases of an unusual vascular lesion occurring in mammary skin after radiation, which they named atypical vascular lesion (AVL).
Atypical vascular lesion usually presents as 1 or more small, flesh-colored papules or erythematous patches that arise in radiated skin.
Antonescu, "Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions
," Genes, Chromosomes and Cancer, vol.