atypical renal cyst

atypical renal cyst

A cystic mass in the kidney lined by flat, cytologically bland cuboidal  epithelium, which focally has simple small papillary projections that become somewhat more complex in the cyst wall.

Aetiology
Sporadic cases, associated with von Hippel-Landau syndrome and end-stage renal disease on dialysis.

DiffDx
Cystic nephroma, simple cysts, cystic papillary renal cell carcinoma.
References in periodicals archive ?
The main differential diagnosis of an atypical renal cyst includes a benign simple cyst and a cystic renal neoplasm.
(187) This section will discuss the 3 most commonly purported precursor lesions of the kidney: atypical renal cysts, papillary adenomas, and renal intraepithelial neoplasia.
(189-191) While it is generally accepted that not all cysts progress to cancer and that not all cancers originate as cysts, several studies have shown a link between atypical renal cysts and malignancy.
Atypical renal cysts may be uniloculated or multiloculated and are lined by multilayered epithelium and/or papillary projections (Figure 6, A).
It also highlights the importance of MRI and serial radiological follow-up for atypical renal cyst with rapid growth that might carry poor prognosis and should prompt surgical management.
(3) Patients with ADPKD may develop Renal Cell Carcinomas (RCC), which typically manifests as atypical renal cysts. Sarcomatous change in these tumours, is thought to be more frequent than in non-ADPKD related tumours.
Atypical renal cysts: a clinicopathologic study of 33 cases.
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