atypical measles
Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to atypical measles: atypical measles syndrome
a·typ·i·cal mea·sles
sometimes severe, unusual clinical manifestation of natural measles virus infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction apparently resulting from an anamnestic antibody response, characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia.
Farlex Partner Medical Dictionary © Farlex 2012
atypical measles
A serious illness that occurred in children immunised with an inactivated vaccine against measles virus in the 1960s, which failed to elicit long-lived protective antibody and a cytotoxic T-lymphocyte response.Clinical findings
High fever, headache, cough, abdominal pain, followed by rash 1 to 2 days later, often beginning on the limbs, acral oedema; pneumonia is common and may persist for 3 months or more.
Pathogenesis
Post-vaccination exposure to wild-type virus during community outbreaks was associated with immune complex deposition in affected tissues, brisk CD4+ T lymphocyte proliferative responses, and a Th2 bias of the immune response.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
a·typ·i·cal mea·sles
(ā-tip'i-kăl mē'zĕlz)Unusual clinical manifestation of natural measles infection in people with waning vaccination immunity, particularly in those who had received formaldehyde-inactivated vaccine; an accelerated allergic reaction characterized by high fever, absence of Koplik spots, a shortened prodromal period, atypical rash, and pneumonia.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012