atypical lobular hyperplasia


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atypical lobular hyperplasia

A relatively uncommon lesion of the female breast characterised by lobules containing uniform dyshesive epithelial cells with eccentric nuclei, often accompanied by intracytoplasmic mucin vacuoles (so-called“private acini”); the surrounding myoepithelial cell layer is retained. It is a non-palpable lesion seen in 1% to 3.6% of female breasts and carries a general increase in the risk of future breast cancer.
References in periodicals archive ?
Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature.
Atypical lobular hyperplasia and classic lobular carcinoma in situ in core biopsy specimens: routine excision is not necessary.
24 for those with atypical lobular hyperplasia, and 8.
In contrast, breast cancer risk in women with atypical lobular hyperplasia remained steady over time.
An MMP-9-positive/ADAM12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia.
Atypical lobular hyperplasia exhibits more genomic alterations compared with LCIS, suggesting that they represent distinct biologic entities.
Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: a retrospective cohort study.
We appreciate the comments on our report examining the necessity of surgical excision for atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) diagnosed on core biopsy.
Atypical lobular hyperplasia was defined as histologic changes of LCIS to a lesser quantitative or qualitative degree.
Lobular carcinoma in situ and atypical lobular hyperplasia at percutaneous biopsy with surgical correlation: a multi-institutional study [abstract].
Cases of atypical lobular hyperplasia and possible phyllodes tumor were coded separately and were excluded.

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