atypical lobular hyperplasia


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atypical lobular hyperplasia

A relatively uncommon lesion of the female breast characterised by lobules containing uniform dyshesive epithelial cells with eccentric nuclei, often accompanied by intracytoplasmic mucin vacuoles (so-called“private acini”); the surrounding myoepithelial cell layer is retained. It is a non-palpable lesion seen in 1% to 3.6% of female breasts and carries a general increase in the risk of future breast cancer.
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Follow-up surgical excision is indicated when breast core needle biopsies show atypical lobular hyperplasia or lobular carcinoma in situ: a correlative study of 33 patients with review of the literature.
Atypical lobular hyperplasia and classic lobular carcinoma in situ in core biopsy specimens: routine excision is not necessary.
Pathologic upgrade rates on subsequent excision when lobular carcinoma in situ is the primary diagnosis in the needle core biopsy with special attention to the radiographic target
24 for those with atypical lobular hyperplasia, and 8.
In contrast, breast cancer risk in women with atypical lobular hyperplasia remained steady over time.
Atypical lobular hyperplasia has higher breast Ca risk than ductal
An MMP-9-positive/ADAM12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia.
Urine test promising for assessing breast cancer risk
Atypical lobular hyperplasia exhibits more genomic alterations compared with LCIS, suggesting that they represent distinct biologic entities.
Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: a retrospective cohort study.
Lobular neoplasia of the breast: an update
We appreciate the comments on our report examining the necessity of surgical excision for atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) diagnosed on core biopsy.
Necessity of surgical excision for atypical lobular hyperplasia and lobular carcinoma in situ
Atypical lobular hyperplasia was defined as histologic changes of LCIS to a lesser quantitative or qualitative degree.
Lobular carcinoma in situ and atypical lobular hyperplasia at percutaneous biopsy with surgical correlation: a multi-institutional study [abstract].
Excisional biopsy should be performed if lobular carcinoma in situ is seen on needle core biopsy
A single focus of atypical lobular hyperplasia was also present.
Bilateral Paget disease of the nipple associated with lobular carcinoma in situ: application of immunohistochemistry to a rare finding
Cases of atypical lobular hyperplasia and possible phyllodes tumor were coded separately and were excluded.
Adequate Histologic Sampling of Breast Core Needle Biopsies

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