atypical lobular hyperplasia


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atypical lobular hyperplasia

A relatively uncommon lesion of the female breast characterised by lobules containing uniform dyshesive epithelial cells with eccentric nuclei, often accompanied by intracytoplasmic mucin vacuoles (so-called“private acini”); the surrounding myoepithelial cell layer is retained. It is a non-palpable lesion seen in 1% to 3.6% of female breasts and carries a general increase in the risk of future breast cancer.
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Lobular carcinoma in situ or atypical lobular hyperplasia at core-needle biopsy: is excisional biopsy necessary?
Triaging Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ on Percutaneous Core Biopsy to Surgery or Observation: Assiduous Radiologic-Pathologic Correlation Works, Quantitating Extent of Disease Does Not
In contrast, breast cancer risk in women with atypical lobular hyperplasia remained steady over time.
Atypical lobular hyperplasia has higher breast Ca risk than ductal
That worked out to an adjusted odds ratio for developing breast cancer of 2.76 for women with atypical ductal hyperplasia, 5.24 for those with atypical lobular hyperplasia, and 8.12 for women with both histologic abnormalities, she continued.
Breast cancer risk differs by subtype of atypical hyperplasia
An MMP-9-positive / ADAM 12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia.
Urine test enhances breast ca risk picture
An MMP-9-positive/ADAM12-negative urine sample conferred a 40% chance that the patient had LCIS and a 25% chance that she had atypical ductal hyperplasia or atypical lobular hyperplasia. And a sample that proved negative for both biomarkers was associated with a zero probability of atypical hyperplasia.
Urine test promising for assessing breast cancer risk
Atypical lobular hyperplasia was diagnosed when acini in a lobular unit had less than 50% involvement by a monotonous population of epithelial cells showing classic lobular characteristics, including discohesive cells with small, round nuclei, often containing perinuclear vacuoles.
Isolated Atypical Lobular Hyperplasia Diagnosed on Breast Biopsy: Low Upgrade Rate on Subsequent Excision With Long-Term Follow-up
The term lobular neoplasia has been applied to the spectrum of lesions comprising atypical lobular hyperplasia (ALH) and LCIS.
Current Concepts in Diagnosis, Molecular Features, and Management of Lobular Carcinoma In Situ of the Breast With a Discussion of Morphologic Variants
Age distributions of patients with carcinoma, atypical ductal hyperplasia (ADH), and atypical lobular hyperplasia (ALH).
Recommendations for Pathologic Evaluation of Reduction Mammoplasty Specimens: A Prospective Study With Systematic Tissue Sampling
Malignant (18%; 31/177) Invasive ductal carcinoma 13 Invasive lobular carcinoma 4 Ductal carcinoma in situ 12 Invasive mixed carcinoma 1 Tubular carcinoma 1 Atypical epithelial hyperplasia (11%; 20/177) Atypical ductal hyperplasia 3 Lobular neoplasia 17 (12 ALH, 5 LCIS) Benign (71%;126/177) Benign breast diagnoses (105/126) Fibrocystic changes with/without 31 epithelial hyperplasia Columnar cell lesions 30 Fibroadenoma and 14 fibroadenomatoid change Ductal ectasia 7 Radial sclerosing lesion 6 Papilloma 7 PASH 5 Intramammary lymph node 3 Fat necrosis 1 Hemangioma 1 Normal breast tissue (21/126) Abbreviations: ALH, atypical lobular hyperplasia; LCIS, lobular carcinoma in situ;PASH, pseudoangiomatous stromal hyperplasia.
Pathologic Findings of Breast Lesions Detected on Magnetic Resonance Imaging
The atypia category included ADH, apocrine atypia, atypical lobular hyperplasia, and classic lobular carcinoma in situ.
Characteristics of a Breast Pathology Consultation Practice
(23) Lobular carcinoma in situ and/ or atypical lobular hyperplasia is associated with tubular carcinoma in approximately half of cases.
Small Glandular Proliferations of the Breast With Absent or Attenuated Myoepithelial Reactivity by Immunohistochemistry: A Review Focusing on the Differential Diagnosis and Interpretative Pitfalls
E-cadherin alterations in atypical lobular hyperplasia and lobular carcinoma in situ of the breast.
Application of Immunohistochemistry in Breast Pathology: A Review and Update

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