atypical lipomatous tumor

atypical lipomatous tumor

Atypical lipoma, well-differentiated liposarcoma Pathology A soft tissue tumor, most often retroperitoneal, also seen in the skin Prognosis ALTs often recur locally, but rarely metastasize.
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Important differential diagnoses of spindle cell lipoma include atypical lipomatous tumor and dedifferentiated liposarcoma.
However, it is important to differentiate a lipoma from an atypical lipomatous tumor, which may have a similar appearance but, unlike a lipoma, can on occasion develop into a cancer (your brother should see an orthopaedic or surgical oncologist if he has any concerns).
INTRODUCTION: Dedifferentiated liposarcoma represents a malignant adipocytic neoplasm showing transition from atypical lipomatous tumor or well-differentiated liposarcoma to nonlipogenic sarcoma of variable histologic grade, usually at least several millimeters in diameter.
Subconjunctival herniated orbital fat: a benign adipocytic lesion that may mimic pleomorphic lipoma and atypical lipomatous tumor.
Spindle cell lipoma lacks the amplification and/or expression of MDM2 and CDK4, a characteristic finding of the variants of atypical lipomatous tumor.
Histologic examination revealed an atypical lipomatous tumor with a remarkably large portion of spindles.
Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor.
In addition, these markers are often helpful in the distinction between benign lipomas, particularly those with prominent fat necrosis, and atypical lipomatous tumor (well-differentiated liposarcoma), particularly when the latter shows very minimal atypical histologic features.
Atypical lipomatous tumor, its variants, and its combined forms: a study of 61 cases, with a minimum follow-up of 10 years.
2,17-19) The differential diagnosis of atypical lipomatous tumor and lipoma exists due to the lipoma-like variant of atypical lipomatous tumor, which can have only scattered atypical cells.
Tumors meeting the classic histopathologic criteria for WDLs that arise in the oral cavity, salivary glands, and other superficial, surgically accessible areas are called atypical lipomatous tumors (ALTs).
In these 10 sections, the authors discuss the general information for each tumor in detail and also include some interesting topics in relevant sections, such as the reasons for retaining the category of fibrous histiocytomas, spindle cell/pleomorphic lipoma versus atypical lipomatous tumors, and problematic smooth muscle tumors of the soft tissues and retroperitoneum.

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