atypical hyperplasia

atypical hyperplasia

A non-specific term for any condition—usually billed as benign—in which cells have abnormal features and are increased in number. 
Note: Without a further adjectival qualifier (e.g., atypical ductal hyperplasia, atypical lobular hyperplasia, complex endometrial hyperplasia with atypia), use of the term atypical hyperplasia is ill-advised, given that it doesn’t convey enough information to decipher the portent of a lesion so labelled.
Endometrium In the endometrium, atypical hyperplasia is associated with carcinoma (in the same biopsy), and even in absence of carcinoma in the original biopsy, carries an increased risk of future development of endometrioid carcinoma. Some cases have been reversed with progestogens.
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It found AI came close to performing as well as doctors in differentiating cancer from non-cancer cases, but the machine managed to outperform doctors when differentiating DCIS from atypical hyperplasia.
Moreover, 2 cases of atypical hyperplasia were upgraded to endometrial Ca in hysterectomies (The International Federation of Gynecology and Obstetrics [FIGO] grade I & II), and there was a single case of Ca detected in biopsy upgraded from FIGO grade I to II in the final diagnosis.
Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma.
Atypical hyperplasia (ADH or atypical lobular hyperplasia) involving a fibroadenoma is an uncommon finding that, when confined to a fibroadenoma, does not carry a meaningful risk of carcinoma (Figure 2, E and F).
It also reduced the incidence of ductal carcinoma in situ (DCIS) by 50%, lobular carcinoma in situ (LCIS) by 56% and atypical hyperplasia by 86%.
After multivariate analysis, diameter of the polyps was the only variable significantly associated with an abnormal histology (malignancy and atypical hyperplasia) in asymptomatic women with an odds ratio of 6.9 (confidence interval: 2.2-21.4) for polyps with mean diameter > 1.8 cm [15].
As endometriosis is an ectopic endometrium, hyperestrogenism may stimulate the transformation of endometriosis into atypical hyperplasia and endometrioid adenocarcinoma, similar to the process by which endometrioid adenocarcinoma has been found to develop in the endometrium [11].
But if the results do not indicate cancer or atypical hyperplasia, the evaluation cannot be considered adequate, much less definitive, especially if bleeding persists.
The initial disease process in Primary Myelofibrosis is a disorder of the clonal haematopoietic stem cells that leads to chronic proliferation of the myeloid cells along with atypical hyperplasia of the megakaryocytes.
Descriptive analyses were used to examine the two groups with regard to the following variables: age, family history, BRCA status, history of biopsy proven atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS), breast cancer histology, stage, estrogen receptor (ER)/progesterone receptor (PR)/HER2/neu status, type of chemopreventive agent used (tamoxifen, raloxifene, or AIs), duration of use, time between primary cancer and subsequent breast malignancy, and location of the breast cancer (contralateral versus ipsilateral).
The disease process that leads to UC-CRC involves "continuous intestinal inflammation, suspicious atypical hyperplasia, a low degree of atypical hyperplasia, and highly atypical hyperplasia and cancer"; however, the later steps can be skipped [8].
We classified the endometrial lesions into four categories: normal endometrium, nonatypical hyperplasia, atypical hyperplasia, and carcinoma.

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