atypical hyperplasia

atypical hyperplasia

A non-specific term for any condition—usually billed as benign—in which cells have abnormal features and are increased in number. 
Note: Without a further adjectival qualifier (e.g., atypical ductal hyperplasia, atypical lobular hyperplasia, complex endometrial hyperplasia with atypia), use of the term atypical hyperplasia is ill-advised, given that it doesn’t convey enough information to decipher the portent of a lesion so labelled.
Endometrium In the endometrium, atypical hyperplasia is associated with carcinoma (in the same biopsy), and even in absence of carcinoma in the original biopsy, carries an increased risk of future development of endometrioid carcinoma. Some cases have been reversed with progestogens.
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In this retrospective study, the mean age of patients with carcinoma or atypical hyperplasia was statistically significantly higher compared with women without carcinoma or atypia.
But if the results do not indicate cancer or atypical hyperplasia, the evaluation cannot be considered adequate, much less definitive, especially if bleeding persists.
Breast cancer risk associated with proliferative breast disease and atypical hyperplasia.
The initial disease process in Primary Myelofibrosis is a disorder of the clonal haematopoietic stem cells that leads to chronic proliferation of the myeloid cells along with atypical hyperplasia of the megakaryocytes.
Taking atypical hyperplasia and carcinoma as positive, the diagnostic accuracy of CB was 95.
These morphological changes are the basis of histological diagnosis and place the endometrium in various categories like secretory phase, proliferative phase, irregular maturation, disordered proliferative, discordance between glands and stroma, simple, complex or atypical hyperplasia and endometrial carcinoma.
Histologically, the prostate tissues of the rats in the BPH group showed atypical hyperplasia of epithelial and stromal tissues, which was characterized by irregular acinar shape with villous projections, dilation of acini, high cylindrical epithelial cells, back-to-back interacinar space, and ischesis (Figure 2C) [16].
Furthermore, synchronous or metachronous occurrence of atypical hyperplasia or endometrioid adenocarcinoma within APA has been reported.
Two patients were found to have increasing endometrial thickness on regular follow up visits endometrial biopsy was carried out which revealed atypical hyperplasia so they were dropped out in favour of definitive surgical treatment.
This supports a theory that myelolipoma and atypical hyperplasia of adrenal cortex may be anatomically and functionally related.
3%), followed by simple or complex atypical hyperplasia (4.
Atypical hyperplasia (AH) significantly increased the relative risk of carcinoma (14; 95% CI 5 38).

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