atypical fibroxanthoma


Also found in: Acronyms.

a·typ·i·cal fi·bro·xan·tho·ma

a solitary, often ulcerated, small, cutaneous, usually benign tumor composed of foamy histiocytes, spindle cells, and bizarre giant cells; usually found on the exposed skin of older people; microscopically, atypical fibroxanthoma closely resembles malignant fibrous histiocytoma, but originates in the dermis.

atypical fibroxanthoma

A cutaneous tumour seen in the head and neck of older individuals, which is linked to sun exposure and radiation therapy. It is characterised by a proliferation of spindle cells, many of which have bizarre and hyperchromatic nuclei, increased mitoses and atypical mitotic figures.
References in periodicals archive ?
Caption: An atypical fibroxanthoma, in a 94-yearold woman, who presented with a 1-month history of an asymptomatic, pink nodule on her left eyebrow: She had a history of nonmelanoma skin cancers on the face.
Atypical fibroxanthoma is a diagnosis of exclusion.
Morphologically and immunohistochemically, the features were consistent with atypical fibroxanthoma. The closest resection margin was found to be 3 millimetres located superiorly.
Kossard, "Procollagen 1 expression in atypical fibroxanthoma and other tumors," Journal of Cutaneous Pathology, vol.
Many secondary changes have been described in atypical fibroxanthoma, such as keloidal areas, myxoid or chondroid changes, osteoclast-like giant cells, sclerosis, fibrosis, pigmentation, hyalinization, or hemorrhagic areas (1-3, 11-19).
Atypical fibroxanthoma (AFX) has been a topic for debate since the 1960s, when Helwig (1) coined its present name.
The differential diagnosis of atypical spindle cell neoplasms on sun-damaged skin includes atypical fibroxanthoma (AFX), spindle cell or desmoplastic melanoma (see melanocytic neoplasms below), spindle cell SCC, and leiomyosarcoma.
Atypical fibroxanthoma (AFX) is a rare neoplasm that shows worrisome clinical and histologic features, but typically carries a good prognosis.
Recent studies showed that CD99 labeled 17 of 17 cases (100%) and 19 of 26 cases (73%) of atypical fibroxanthoma, with most showing a moderate to strong staining pattern.
Cases with atypical cytologic characteristics may simulate atypical fibroxanthoma, leiomyosarcoma, malignant peripheral nerve sheath tumors, other sarcomas, or sarcomatoid carcinomas.
Both squamous cell carcinoma and atypical fibroxanthoma arise on sun-damaged skin.
It has also been demonstrated recently in the majority of xanthomatous skin lesions, (8) atypical fibroxanthomas, typical dermatofibromas, and occasional epithelioid dermatofibromas.

Full browser ?