atypical ductal hyperplasia


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

atypical ductal hyperplasia

Premalignant lesion of the breast ducts.

atypical ductal hyperplasia

Breast An intraductal lesion characterised by the proliferation of evenly distributed monomorphic epithelial cells which are morphologically identical to those seen in DCIS. ADH differs from DCIS as it involves less than 2 membrane-bound spaces or measures less than 2 mm and is usually confined to a single lobular unit.
Pancreas Pancreatic intraepithelial neoplasia, see there.

atypical ductal hyperplasia

Abbreviation: ADH
A premalignant lesion of the breast. It is often found in biopsy specimens of patients with breast cancer. It is characterized by a small number of breast ducts with abnormal cellular and glandular structures. It is hypothesized that atypical ductal hyperplasia is one of several breast lesions that can develop into ductal carcinoma in situ and, ultimately, into an invasive cancer.
See also: hyperplasia
References in periodicals archive ?
We did not expect to find a decline in rate of atypical ductal hyperplasia with a decline in postmenopausal hormone treatment use," Kerlikowske added.
Caption: Cases of borderline atypia with the differential diagnosis of benign usual ductal hyperplasia (UDH) and atypical ductal hyperplasia (ADH), which had final diagnoses of UDH (A) and ADH (B).
Underestimation of atypical ductal hyperplasia at MRI-guided 9-gauge vacuum-assisted breast.
Rigid arches and punched-out space involving a single acinus in keeping with atypical ductal hyperplasia (hematoxylin-eosin, original magnification X40).
The spectrum of intraductal papillary lesions comprises intraductal papilloma, papilloma with atypical ductal hyperplasia (ADH), papilloma with ductal carcinoma in situ (DCIS), and intraductal papillary carcinoma.
1,2) Atypical ductal hyperplasia (ADH) is associated with a 3- to 5-fold increase in relative risk of subsequent development of cancer, compared with women without ADH.
Atypical ductal hyperplasia and ductal carcinoma in situ can occasionally show extravasated mucin.
Needle core biopsies containing coexisting atypical ductal hyperplasia (ADH), lobular carcinoma in situ (LClS)/atypical lobular hyperplasia (ALH), and papillary lesions were excluded.
Atypical ductal hyperplasia of the breast: clonal proliferation with loss of heterozygosity on chromosomes 16q and 17p.
In the Nurses' Health Study, (18,19) the Mayo Clinic Cohort, (20) and the Nashville Cohort, (21,22) 4% to 9% of breast biopsies contained atypical ductal hyperplasia (ADH) or atypical lobular hyperplasia (ALH).
9) Alternatively, the staining pattern of CK5/6 is extremely helpful in differentiating usual ductal hyperplasia from atypical ductal hyperplasia (ADH) and DCIS.
Discrepancy in interpretations between reads using either WSI or OM by the same pathologist and between pathologists occurred with selected lesions such as florid hyperplasia, atypical ductal hyperplasia, ductal carcinoma in situ with or without microinvasion, and papillary lesions.

Full browser ?